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Mortality in COVID-19 disease patients: Correlating the association of major histocompatibility complex (MHC) with severe acute respiratory syndrome 2 (SARS-CoV-2) variants.
de Sousa, Eric; Ligeiro, Dário; Lérias, Joana R; Zhang, Chao; Agrati, Chiara; Osman, Mohamed; El-Kafrawy, Sherif A; Azhar, Esam I; Ippolito, Giuseppe; Wang, Fu-Sheng; Zumla, Alimuddin; Maeurer, Markus.
  • de Sousa E; ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal. Electronic address: eric.desousa@research.fchampalimaud.org.
  • Ligeiro D; Lisbon Centre for Blood and Transplantation (Instituto Português do Sangue e Transplantação, IPST, Lisbon, Portugal. Electronic address: dario@ipst.min-saude.pt.
  • Lérias JR; ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal. Electronic address: joana.lerias@research.fchampalimaud.org.
  • Zhang C; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China. Electronic address: zhangch302@163.com.
  • Agrati C; National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy. Electronic address: chiara.agrati@inmi.it.
  • Osman M; York Biomedical Research Institute, University of York, United Kingdom and Emerging and Re-Emerging Diseases, University of Khartoum, Sudan. Electronic address: mohamed.osman@york.ac.uk.
  • El-Kafrawy SA; Special Infectious Agent Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: saelkfrawy@kau.edu.sa.
  • Azhar EI; Special Infectious Agent Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Electronic address: eazhar@kau.edu.sa.
  • Ippolito G; National Institute for Infectious Diseases, Lazzaro Spallanzani, Rome, Italy. Electronic address: giuseppe.ippolito@inmi.it.
  • Wang FS; Treatment and Research Center for Infectious Diseases, The Fifth Medical Center of PLA General Hospital, National Clinical Research Center for Infectious Diseases, Beijing 100039, China. Electronic address: fswang302@163.com.
  • Zumla A; Division of Infection and Immunity, University College London and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, UK. Electronic address: a.zumla@ucl.ac.uk.
  • Maeurer M; ImmunoSurgery Unit, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal; I Medical Clinical, University of Mainz, Germany. Electronic address: markus.maeurer@fundacaochampalimaud.pt.
Int J Infect Dis ; 98: 454-459, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-653180
ABSTRACT
Genetic factors such as the HLA type of patients may play a role in regard to disease severity and clinical outcome of patients with COVID-19. Taking the data deposited in the GISAID database, we made predictions using the IEDB analysis resource (TepiTool) to gauge how variants in the SARS-CoV-2 genome may change peptide binding to the most frequent MHC-class I and -II alleles in Africa, Asia and Europe. We caracterized how a single mutation in the wildtype sequence of of SARS-CoV-2 could influence the peptide binding of SARS-CoV-2 variants to MHC class II, but not to MHC class I alleles. Assuming the ORF8 (L84S) mutation is biologically significant, selective pressure from MHC class II alleles may select for viral varients and subsequently shape the quality and quantity of cellular immune responses aginast SARS-CoV-2. MHC 4-digit typing along with viral sequence analysis should be considered in studies examining clinical outcomes in patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Histocompatibility Antigens Class I / Histocompatibility Antigens Class II / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa / Asia / Europa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Histocompatibility Antigens Class I / Histocompatibility Antigens Class II / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Topics: Variants Limits: Humans Country/Region as subject: Africa / Asia / Europa Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article