SARS-CoV2 and pregnancy: An invisible enemy?
Am J Reprod Immunol
; 84(5): e13308, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-654180
ABSTRACT
Coronavirus disease 2019 or COVID-19 is an emerging viral disease caused by a member of the betacoronavirus family, SARS-CoV-2. Since its' emergence in December 2019, it has rapidly caused close to half a million fatalities globally. Data regarding the impact of COVID-19 on pregnancy are limited. Here, we review pathological findings in placentas from women who tested positive for SARS-CoV-2 as well as information on pregnancy outcomes associated with related and highly pathogenic coronaviruses (ie, severe acute respiratory syndrome (SARS-COV) and the Middle East respiratory syndrome, MERS). We present immune-inflammatory correlates of COVID-19 in pregnancy and review the role of the Renin Angiotensin System in the pathogenesis of COVID-19 in pregnancy. Greater understanding of the pathogenesis of SARS-CoV-2 in the placenta will yield important insight into potential therapeutic interventions for pregnant women with COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Placenta
/
Pregnancy Complications, Infectious
/
Renin-Angiotensin System
/
Pregnancy
/
SARS-CoV-2
/
COVID-19
Type of study:
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Am J Reprod Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Aji.13308
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