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SARS-CoV-2-related pneumonia can be successfully managed in patients with metastatic neuroendocrine tumors: a critical point of view.
Spada, F; Pellicori, S; Zampino, G; Funicelli, L; Gervaso, L; Laffi, A; Rubino, M; Garcia-Carbonero, R; Fazio, N.
  • Spada F; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Pellicori S; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Zampino G; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Funicelli L; Division of Radiology, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Gervaso L; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Laffi A; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Rubino M; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy.
  • Garcia-Carbonero R; Medical Oncology Department, Hospital Universitario Doce de Octubre, Imas12, UCM, Madrid, Spain.
  • Fazio N; Division of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology (IEO), IRCCS, Via Ripamonti 435, 20141, Milan, Italy. nicola.fazio@ieo.it.
Endocrine ; 70(1): 6-10, 2020 10.
Article in English | MEDLINE | ID: covidwho-654265
ABSTRACT
Primary neuroendocrine tumors of the thymus are extremely rare. In patients with advanced disease, tumor growth control, and sometimes also syndrome control are the main goals of systemic therapy. Unfortunately, no standard therapies are available in clinical practice; therefore, clinical studies are strongly recommended. Axitinib (AXI) is a tyrosine kinase inhibitor, currently under investigation in an international phase II/III trial including thymic neuroendocrine tumors. Over the past 5 months, the entire world has been facing a devastating medical emergency brought about by a pandemic due to a novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China, in late 2019. Since then, health professionals have been expending all their efforts on trying to provide the best available treatments for patients involved. Patients with cancer, especially those with thoracic involvement, are at higher risk of coronavirus disease 19 (COVID-19) and its complications because of their immunosuppressive status caused by the cancer and the anticancer therapies. As it remains unclear how to optimally manage such patients, we wished to report our experience with a patient with a metastatic neuroendocrine tumor of the thymus infected with SARS-CoV-2 in the hope that it may provide some insights and reflections on the management of cancer patients during this challenging time in our history.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thymus Neoplasms / Carcinoid Tumor / Neuroendocrine Tumors / Coronavirus Infections / Betacoronavirus Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2020 Document Type: Article Affiliation country: S12020-020-02419-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thymus Neoplasms / Carcinoid Tumor / Neuroendocrine Tumors / Coronavirus Infections / Betacoronavirus Type of study: Case report / Diagnostic study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: Endocrine Journal subject: Endocrinology Year: 2020 Document Type: Article Affiliation country: S12020-020-02419-w