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Why continuing uncertainties are no reason to postpone challenge trials for coronavirus vaccines.
Steel, Robert; Buchak, Lara; Eyal, Nir.
  • Steel R; Center for Population-Level Bioethics and Department of Philosophy, Rutgers University, New Brunswick, New Jersey, USA.
  • Buchak L; Department of Philosophy, Princeton University, Princeton, NJ, USA.
  • Eyal N; Center for Population-Level Bioethics; Department of Philosophy, School of Arts and Sciences; Department of Health Behavior, Society and Policy, Rutgers School of Public Health, Rutgers University, New Brunswick, New Jersey, USA neyal@cplb.rutgers.edu.
J Med Ethics ; 46(12): 808-812, 2020 12.
Article in English | MEDLINE | ID: covidwho-654957
ABSTRACT
To counter the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), some have proposed accelerating SARS-CoV-2 vaccine development through controlled human infection (or 'challenge') trials. These trials would involve the deliberate exposure of relatively few young, healthy volunteers to SARS-CoV-2. We defend this proposal against the charge that there is still too much uncertainty surrounding the risks of COVID-19 to responsibly run such a trial.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clinical Trials as Topic / Biomedical Research / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Med Ethics Year: 2020 Document Type: Article Affiliation country: Medethics-2020-106501

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Clinical Trials as Topic / Biomedical Research / COVID-19 Vaccines / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: J Med Ethics Year: 2020 Document Type: Article Affiliation country: Medethics-2020-106501