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COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
Nishiga, Masataka; Wang, Dao Wen; Han, Yaling; Lewis, David B; Wu, Joseph C.
  • Nishiga M; Stanford Cardiovascular Institute, Stanford, CA, USA. mnishiga@stanford.edu.
  • Wang DW; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. mnishiga@stanford.edu.
  • Han Y; Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
  • Lewis DB; Cardiovascular Research Institute, Department of Cardiology, General Hospital of Northern Theater Command, Shenyang, China.
  • Wu JC; Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Nat Rev Cardiol ; 17(9): 543-558, 2020 09.
Article in English | MEDLINE | ID: covidwho-655692
ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by a strain of coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic that has affected the lives of billions of individuals. Extensive studies have revealed that SARS-CoV-2 shares many biological features with SARS-CoV, the zoonotic virus that caused the 2002 outbreak of severe acute respiratory syndrome, including the system of cell entry, which is triggered by binding of the viral spike protein to angiotensin-converting enzyme 2. Clinical studies have also reported an association between COVID-19 and cardiovascular disease. Pre-existing cardiovascular disease seems to be linked with worse outcomes and increased risk of death in patients with COVID-19, whereas COVID-19 itself can also induce myocardial injury, arrhythmia, acute coronary syndrome and venous thromboembolism. Potential drug-disease interactions affecting patients with COVID-19 and comorbid cardiovascular diseases are also becoming a serious concern. In this Review, we summarize the current understanding of COVID-19 from basic mechanisms to clinical perspectives, focusing on the interaction between COVID-19 and the cardiovascular system. By combining our knowledge of the biological features of the virus with clinical findings, we can improve our understanding of the potential mechanisms underlying COVID-19, paving the way towards the development of preventative and therapeutic solutions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Nat Rev Cardiol Journal subject: Cardiology Year: 2020 Document Type: Article Affiliation country: S41569-020-0413-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cardiovascular Diseases / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Nat Rev Cardiol Journal subject: Cardiology Year: 2020 Document Type: Article Affiliation country: S41569-020-0413-9