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Evaluation of a novel blood microsampling device for clinical trial sample collection and protein biomarker analysis.
Xing, Jinming; Loureiro, Joseph; Patel, Michael T; Mikhailov, Dmitri; Gusev, Arkady I.
  • Xing J; Biomarker Development, Novartis Institutes for BioMedical Research, 220 Massachusetts Ave, Cambridge, MA 02139, USA.
  • Loureiro J; Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, 250 Massachusetts Ave, Cambridge, MA 02139, USA.
  • Patel MT; Biomarker Development, Novartis Institutes for BioMedical Research, 220 Massachusetts Ave, Cambridge, MA 02139, USA.
  • Mikhailov D; Biopharmaceutical Industry Fellowship Program, Massachusetts College of Pharmacy & Health Sciences University, 179 Longwood Ave, Boston, MA 02115, USA.
  • Gusev AI; Biomarker Development, Novartis Institutes for BioMedical Research, 220 Massachusetts Ave, Cambridge, MA 02139, USA.
Bioanalysis ; 12(13): 919-935, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-656243
ABSTRACT

Aim:

Evaluation of a novel microsampling device for its use in clinical sample collection and biomarker analysis.

Methodology:

Matching samples were collected from 16 healthy donors (ten females, six males; age 42 ± 20) via K2EDTA touch activated phlebotomy (TAP) device and phlebotomy. The protein profile differences between sampling groups was evaluated using aptamer-based proteomic assay SomaScan and selected ELISA.

Conclusion:

Somascan signal concordance between phlebotomy- and TAP-generated samples was studied and comparability of protein abundances between these blood sample collection methods was demonstrated. Statistically significant correlation in selected ELISA assays also confirmed the TAP device applicability to the quantitative analysis of protein biomarkers in clinical trials.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Proteins / Phlebotomy Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Bioanalysis Year: 2020 Document Type: Article Affiliation country: Bio-2020-0063

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Proteins / Phlebotomy Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Bioanalysis Year: 2020 Document Type: Article Affiliation country: Bio-2020-0063