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Haematological and immunological data of Chinese children infected with coronavirus disease 2019.
Xiong, Xiaoli; Chua, Gilbert T; Chi, Shuiqing; Kwan, Mike Yat Wah; Wong, Wilfred Hing Sang; Zhou, Aifen; Shek, Chi Chiu; Tung, Keith T S; Qin, Huan; Wong, Rosa S; Li, Xue; Chen, Peng; Li, Shuai; Chui, Celine S; Tso, Winnie W Y; Ho, Marco H K; Wong, Ian C K; Chan, Godfrey C F; Lau, Yu Lung; Wong, Kenneth K Y; Chung, Patrick H Y; Li, Hui; Tam, Paul K H; Tang, Shao-Tao; Lp, Patrick.
  • Xiong X; Department of Integrated Chinese and Western Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chua GT; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Chi S; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Kwan MYW; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
  • Wong WHS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Zhou A; Department of Maternal Healthcare, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Shek CC; Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Hong Kong SAR, China.
  • Tung KTS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Qin H; Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wong RS; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Li X; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Chen P; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
  • Li S; Department of Respiratory Medicine, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chui CS; Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tso WWY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Ho MHK; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
  • Wong ICK; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Chan GCF; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Lau YL; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China.
  • Wong KKY; Research Department of Practice and Policy, UCL School of Pharmacy, University College, London, United Kingdom.
  • Chung PHY; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Li H; Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Hong Kong SAR, China.
  • Tam PKH; Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
  • Tang ST; Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China.
  • Lp P; Department of Hematology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Data Brief ; 31: 105953, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-656394
ABSTRACT
Haematological and immunological data of children with COVID-19 infection is lacking. Between 21st January and 20th March 2020, 244 children who were confirmed to have COVID-19 infection and admitted to the Wuhan Children's Hospital, China were retrospectively reviewed. 193 children were considered as symptomatic, which was defined as having either the presence of clinical symptoms or the presence of CT thorax abnormalities. Their haematological and immunological profiles, including complete blood counts, lymphocyte subsets (T, B and NK cell counts), immunoglobulin (Ig) profiles (IgG, IgA and IgM) and cytokine profiles were analysed and compared between the symptomatic and asymptomatic groups. The median values and the interquartile ranges were calculated. Comparison was made using the Mann-Whitney U test. Children with symptomatic COVID-19 infection had significantly lower haemoglobin levels, but higher absolute lymphocyte and monocyte counts, IgG and IgA levels, as well as interleukin 6 (IL-6), IL-10, tumour necrosis factor alpha and interferon gamma levels. The obtained data will be utilized for further studies in comparing children and adults with COVID-19 infections in other parts of the world and with different severity .
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Data Brief Year: 2020 Document Type: Article Affiliation country: J.dib.2020.105953

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Language: English Journal: Data Brief Year: 2020 Document Type: Article Affiliation country: J.dib.2020.105953