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Hyperinflammatory Syndrome in Children Associated With COVID-19: Need for Awareness.
Bhat, Chandrika S; Gupta, Latika; Balasubramanian, S; Singh, Surjit; Ramanan, Athimalaipet V.
  • Bhat CS; Pediatric Rheumatology Service, Rainbow Children's Hospital, Bangalore, Karnataka, India. Correspondence: Dr Chandrika S Bhat, Rainbow Children's Hospital, Marathahalli, Bengaluru 560 037, Karnataka, India.
  • Gupta L; Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh India.
  • Balasubramanian S; Department of Pediatrics, Kanchi Kamakoti CHILDS Trust Hospital, Chennai, Tamil Nadu, India.
  • Singh S; Allergy Immunology Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
  • Ramanan AV; Bristol Royal Hospital for Children and Translational Health Sciences, University of Bristol, Bristol, UK.
Indian Pediatr ; 57(10): 929-935, 2020 Oct 15.
Article in English | MEDLINE | ID: covidwho-656489
ABSTRACT
The pandemic of COVID-19 initially appeared to cause only a mild illness in children. However, it is now apparent that a small percentage of children can develop a hyperinflammatory syndrome labeled as Pediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS). Features of this newly recognized condition may include persistent fever, evidence of inflammation, and single or multi-organ dysfunction in the absence of other known infections. Some of these children may share features of Kawasaki disease, toxic shock syndrome or cytokine storm syndrome. They can deteriorate rapidly and may need intensive care support as well. The PCR test is more often negative; although, most of the children have antibodies to SARS-CoV-2. Although the pathogenesis is not clearly known, immune-mediated injury has been implicated. We herein provide current information on this condition, in order to raise awareness amongst pediatricians.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome / Pandemics Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Indian Pediatr Year: 2020 Document Type: Article Affiliation country: India

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome / Pandemics Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Infant, Newborn Language: English Journal: Indian Pediatr Year: 2020 Document Type: Article Affiliation country: India