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Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.
de Oliveira, Miriane; De Sibio, Maria Teresa; Mathias, Lucas Solla; Rodrigues, Bruna Moretto; Sakalem, Marna Eliana; Nogueira, Célia Regina.
  • de Oliveira M; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. Electronic address: miriane.oliveira@unesp.br.
  • De Sibio MT; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Mathias LS; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Rodrigues BM; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Sakalem ME; Department of Anatomy, Londrina State University (UEL), Londrina, Parana, Brazil.
  • Nogueira CR; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Mol Cell Endocrinol ; 515: 110917, 2020 09 15.
Article in English | MEDLINE | ID: covidwho-661768
Semantic information from SemMedBD (by NLM)
1. FNDC5 gene|FNDC5 INTERACTS_WITH Genes
Subject
FNDC5 gene|FNDC5
Predicate
INTERACTS_WITH
Object
Genes
2. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
3. angiotensin converting enzyme 2 ASSOCIATED_WITH Virus Diseases
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Virus Diseases
4. Disease Outcome PROCESS_OF Patients
Subject
Disease Outcome
Predicate
PROCESS_OF
Object
Patients
5. angiotensin converting enzyme 2 AFFECTS Virus Replication
Subject
angiotensin converting enzyme 2
Predicate
AFFECTS
Object
Virus Replication
6. subcutaneous LOCATION_OF Adipocytes
Subject
subcutaneous
Predicate
LOCATION_OF
Object
Adipocytes
7. Genes INTERACTS_WITH Adipocytes
Subject
Genes
Predicate
INTERACTS_WITH
Object
Adipocytes
8. paired basic amino acid cleaving enzyme AUGMENTS Biological Processes
Subject
paired basic amino acid cleaving enzyme
Predicate
AUGMENTS
Object
Biological Processes
9. ADAM10 gene|ADAM10 AUGMENTS Biological Processes
Subject
ADAM10 gene|ADAM10
Predicate
AUGMENTS
Object
Biological Processes
10. FNDC5 gene|FNDC5 ASSOCIATED_WITH Virus Diseases
Subject
FNDC5 gene|FNDC5
Predicate
ASSOCIATED_WITH
Object
Virus Diseases
11. Coronavirus Infections INTERACTS_WITH 2019 novel coronavirus
Subject
Coronavirus Infections
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
12. Gene INTERACTS_WITH C1426803|252995
Subject
Gene
Predicate
INTERACTS_WITH
Object
C1426803|252995
13. FNDC5 gene|FNDC5 INTERACTS_WITH Genes
Subject
FNDC5 gene|FNDC5
Predicate
INTERACTS_WITH
Object
Genes
14. Obesity PROCESS_OF Patients
Subject
Obesity
Predicate
PROCESS_OF
Object
Patients
15. angiotensin converting enzyme 2 ASSOCIATED_WITH Virus Diseases
Subject
angiotensin converting enzyme 2
Predicate
ASSOCIATED_WITH
Object
Virus Diseases
16. Disease Outcome PROCESS_OF Patients
Subject
Disease Outcome
Predicate
PROCESS_OF
Object
Patients
17. angiotensin converting enzyme 2 AFFECTS Virus Replication
Subject
angiotensin converting enzyme 2
Predicate
AFFECTS
Object
Virus Replication
18. subcutaneous LOCATION_OF Adipocytes
Subject
subcutaneous
Predicate
LOCATION_OF
Object
Adipocytes
19. Genes INTERACTS_WITH Adipocytes
Subject
Genes
Predicate
INTERACTS_WITH
Object
Adipocytes
20. paired basic amino acid cleaving enzyme AUGMENTS Biological Processes
Subject
paired basic amino acid cleaving enzyme
Predicate
AUGMENTS
Object
Biological Processes
21. ADAM10 gene|ADAM10 AUGMENTS Biological Processes
Subject
ADAM10 gene|ADAM10
Predicate
AUGMENTS
Object
Biological Processes
22. FNDC5 gene|FNDC5 ASSOCIATED_WITH Virus Diseases
Subject
FNDC5 gene|FNDC5
Predicate
ASSOCIATED_WITH
Object
Virus Diseases
23. Coronavirus Infections INTERACTS_WITH 2019 novel coronavirus
Subject
Coronavirus Infections
Predicate
INTERACTS_WITH
Object
2019 novel coronavirus
24. Genes, Regulator INTERACTS_WITH FNDC5 gene|FNDC5
Subject
Genes, Regulator
Predicate
INTERACTS_WITH
Object
FNDC5 gene|FNDC5
ABSTRACT
Obesity patients are more susceptible to develop COVID-19 severe outcome due to the role of angiotensin-converting enzyme 2 (ACE2) in the viral infection. ACE2 is regulated in the human cells by different genes associated with increased (TLR3, HAT1, HDAC2, KDM5B, SIRT1, RAB1A, FURIN and ADAM10) or decreased (TRIB3) virus replication. RNA-seq data revealed 14857 genes expressed in human subcutaneous adipocytes, including genes mentioned above. Irisin treatment increased by 3-fold the levels of TRIB3 transcript and decreased the levels of other genes. The decrease in FURIN and ADAM10 expression enriched diverse biological processes, including extracellular structure organization. Our results, in human subcutaneous adipocytes cell culture, indicate a positive effect of irisin on the expression of multiple genes related to viral infection by SARS-CoV-2; furthermore, translatable for other tissues and organs targeted by the novel coronavirus and present, thus, promising approaches for the treatment of COVID-19 infection as therapeutic strategy to decrease ACE2 regulatory genes.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation / Fibronectins / Adipocytes Type of study: Prognostic study Language: English Journal: Mol Cell Endocrinol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gene Expression Regulation / Fibronectins / Adipocytes Type of study: Prognostic study Language: English Journal: Mol Cell Endocrinol Year: 2020 Document Type: Article