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Saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients: a scoping review.
Fakheran, Omid; Dehghannejad, Mandana; Khademi, Abbasali.
  • Fakheran O; Dental research center, Department of Periodontics, Dental Research Institute, Isfahan University of Medical sciences, Isfahan, Iran.
  • Dehghannejad M; Dental Research Center, Dental Research Institute, Isfahan University of Medical sciences, Isfahan, Iran.
  • Khademi A; Dental Research Center, Department of Endodontics, Faculty of Dentistry, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. muikhademi@gmail.com.
Infect Dis Poverty ; 9(1): 100, 2020 Jul 22.
Article in English | MEDLINE | ID: covidwho-662434
ABSTRACT

BACKGROUND:

From the begging months of 2020 a severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called 2019-nCoV) caused a devastating global outbreak. At present, the diagnosis of coronavirus disease 2019 (COVID-19) is made through a nasopharyngeal swab based on reverse transcription polymerase chain reaction (RT-PCR) technique. However, some recent studies suggested the possible role of oral fluids and saliva in the detection of SARS-CoV-2. The purpose of this scoping review is evaluating the available evidence regarding the efficacy of saliva as a diagnostic specimen in COVID-19 patients.

METHODS:

A systematic literature review of six databases (PubMed, Scopus, The Cochrane Central Register of Controlled Trials [CENTRAL], Science Direct, Web of Science and Google scholar) was carried out without any restrictions on date of publication to identify the reliability of saliva as a diagnostic specimen for detection of SARS-CoV-2 in suspected patients.

RESULTS:

Nine eligible articles were included in this review based on our described method. All the included studies are based on clinical surveys among patients with confirmed SARS-CoV-2 infection. Most of studies included in this review, reported that there is no statistically significant difference between nasopharyngeal or sputum specimens and saliva samples regarding viral load.

CONCLUSIONS:

Despite limitations of this study, the findings of this review suggest that the use of self-collected saliva as a non-invasive specimen has proper accuracy and reliability regarding detection of SARS-CoV-2 based on RT-PCR technique.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Saliva / Coronavirus Infections / Viral Load / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00728-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Saliva / Coronavirus Infections / Viral Load / Betacoronavirus Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Infect Dis Poverty Year: 2020 Document Type: Article Affiliation country: S40249-020-00728-w