Viral subversion of nonsense-mediated mRNA decay.
RNA
; 26(11): 1509-1518, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-662475
ABSTRACT
Viruses have evolved in tandem with the organisms that they infect. Afflictions of the plant and animal kingdoms with viral infections have forced the host organism to evolve new or exploit existing systems to develop the countermeasures needed to offset viral insults. As one example, nonsense-mediated mRNA decay, a cellular quality-control mechanism ensuring the translational fidelity of mRNA transcripts, has been used to restrict virus replication in both plants and animals. In response, viruses have developed a slew of means to disrupt or become insensitive to NMD, providing researchers with potential new reagents that can be used to more fully understand the NMD mechanism.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viruses
/
Host-Pathogen Interactions
/
Nonsense Mediated mRNA Decay
Limits:
Animals
/
Humans
Language:
English
Journal:
RNA
Journal subject:
Molecular Biology
Year:
2020
Document Type:
Article
Affiliation country:
Rna.076687.120
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