Are superantigens the cause of cytokine storm and viral sepsis in severe COVID-19? Observations and hypothesis.
Scand J Immunol
; 92(6): e12944, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-662490
ABSTRACT
Right now the world is going through an unprecedented pandemic caused by a novel coronavirus. Recent papers pointed out the fatal outcome in most of the severe cases, in which a cytokine storm has been proven to be the cause of a systemic shock, acute respiratory syndrome, multiorgan failure and consequently death. Several explanations have been proposed trying to explain the pathophysiology of the cytokine storm, but viral proteins with a possible superantigen activity as a cause of immune dysregulation have not been addressed. If this hypothesis is proven, a different treatment approach might change the outcome in severe cases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Dendritic Cells
/
CD4-Positive T-Lymphocytes
/
Superantigens
/
Sepsis
/
SARS-CoV-2
/
COVID-19
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Scand J Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Sji.12944
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