The molecular virology of coronaviruses.
J Biol Chem
; 295(37): 12910-12934, 2020 09 11.
Article
in English
| MEDLINE | ID: covidwho-663881
ABSTRACT
Few human pathogens have been the focus of as much concentrated worldwide attention as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID-19. Its emergence into the human population and ensuing pandemic came on the heels of severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), two other highly pathogenic coronavirus spillovers, which collectively have reshaped our view of a virus family previously associated primarily with the common cold. It has placed intense pressure on the collective scientific community to develop therapeutics and vaccines, whose engineering relies on a detailed understanding of coronavirus biology. Here, we present the molecular virology of coronavirus infection, including its entry into cells, its remarkably sophisticated gene expression and replication mechanisms, its extensive remodeling of the intracellular environment, and its multifaceted immune evasion strategies. We highlight aspects of the viral life cycle that may be amenable to antiviral targeting as well as key features of its biology that await discovery.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Gene Expression Regulation, Viral
/
Coronavirus Infections
/
Coronavirus
/
Virus Physiological Phenomena
Topics:
Vaccines
Limits:
Animals
/
Humans
Language:
English
Journal:
J Biol Chem
Year:
2020
Document Type:
Article
Affiliation country:
Jbc.REV120.013930
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