Clinical molecular genetics evaluation in women with reproductive failures.
Am J Reprod Immunol
; 85(4): e13313, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-669908
ABSTRACT
Molecular diagnostics is a rapidly growing branch of the clinical laboratory and has accelerated the advance of personalized medicine in the fields of pharmacogenomics, pharmacogenetics, and nutrigenomics. The versatility of molecular biology allows it to be effective in several medical fields that include reproduction, immunogenetics, and virology. Implementation of molecular and sequencing technology in reproductive medicine can add another layer of understanding to better define the causes behind infertility and recurrent reproductive loss. In the following, we examine current molecular methods for probing factors behind reproductive pregnancy loss including reverse transcription polymerase chain reaction and next generation sequencing (NGS). We review several current and potential genetic (DNA) and transcriptional (RNA)-based parameters in women with infertility that can be significant in diagnosis and treatment. These molecular factors can be inferred either from genomic DNA or RNA locally within the endometrium. Furthermore, we consider infection-based abnormalities such as human herpesvirus-6 and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Finally, we present future directions as well as data demonstrating the potential role of human endogenous retroviruses in pregnancy loss. We hope these discussions will assist the clinician in delineating some of the intricate molecular factors that can contribute to infertility and recurrent reproductive failures.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Abortion, Spontaneous
/
Gene Expression Regulation
/
Herpesvirus 6, Human
/
Roseolovirus Infections
/
SARS-CoV-2
/
COVID-19
/
Infertility, Female
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Female
/
Humans
Language:
English
Journal:
Am J Reprod Immunol
Year:
2021
Document Type:
Article
Affiliation country:
Aji.13313
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