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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
Codo, Ana Campos; Davanzo, Gustavo Gastão; Monteiro, Lauar de Brito; de Souza, Gabriela Fabiano; Muraro, Stéfanie Primon; Virgilio-da-Silva, João Victor; Prodonoff, Juliana Silveira; Carregari, Victor Corasolla; de Biagi Junior, Carlos Alberto Oliveira; Crunfli, Fernanda; Jimenez Restrepo, Jeffersson Leandro; Vendramini, Pedro Henrique; Reis-de-Oliveira, Guilherme; Bispo Dos Santos, Karina; Toledo-Teixeira, Daniel A; Parise, Pierina Lorencini; Martini, Matheus Cavalheiro; Marques, Rafael Elias; Carmo, Helison R; Borin, Alexandre; Coimbra, Laís Durço; Boldrini, Vinícius O; Brunetti, Natalia S; Vieira, Andre S; Mansour, Eli; Ulaf, Raisa G; Bernardes, Ana F; Nunes, Thyago A; Ribeiro, Luciana C; Palma, Andre C; Agrela, Marcus V; Moretti, Maria Luiza; Sposito, Andrei C; Pereira, Fabrício Bíscaro; Velloso, Licio Augusto; Vinolo, Marco Aurélio Ramirez; Damasio, André; Proença-Módena, José Luiz; Carvalho, Robson Francisco; Mori, Marcelo A; Martins-de-Souza, Daniel; Nakaya, Helder I; Farias, Alessandro S; Moraes-Vieira, Pedro M.
  • Codo AC; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Monteiro LB; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • de Souza GF; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Muraro SP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Virgilio-da-Silva JV; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Prodonoff JS; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Carregari VC; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • de Biagi Junior CAO; Department of Genetics at Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil.
  • Crunfli F; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Jimenez Restrepo JL; Department of Clinical and Toxicological analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Vendramini PH; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Reis-de-Oliveira G; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Bispo Dos Santos K; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Toledo-Teixeira DA; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Parise PL; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Martini MC; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Marques RE; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil.
  • Carmo HR; Department of Clinical Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Borin A; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil.
  • Coimbra LD; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil.
  • Boldrini VO; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Brunetti NS; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Vieira AS; Department of Animal Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Mansour E; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Ulaf RG; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Bernardes AF; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Nunes TA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Ribeiro LC; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Palma AC; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Agrela MV; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Moretti ML; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Sposito AC; Department of Clinical Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil.
  • Pereira FB; Hematology and Hemotherapy Center University of Campinas, Campinas, São Paulo, Brazil.
  • Velloso LA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil.
  • Vinolo MAR; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil.
  • Damasio A; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil.
  • Proença-Módena JL; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.
  • Carvalho RF; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
  • Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Bra
  • Martins-de-Souza D; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil; D'Or Institute for Research and Education (IDOR), São Paulo, Brazil; Instituto Nacional
  • Nakaya HI; Department of Clinical and Toxicological analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Farias AS; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil.
  • Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil; Experimental Medicine Research Clust
Cell Metab ; 32(3): 437-446.e5, 2020 09 01.
Article in English | MEDLINE | ID: covidwho-670096
ABSTRACT
COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis. HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs to treat COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Monocytes / Coronavirus Infections / Diabetes Complications / Hypoxia-Inducible Factor 1, alpha Subunit / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: J.cmet.2020.07.007

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Monocytes / Coronavirus Infections / Diabetes Complications / Hypoxia-Inducible Factor 1, alpha Subunit / Betacoronavirus Type of study: Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: J.cmet.2020.07.007