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Interleukin-6 in Rheumatoid Arthritis.
Pandolfi, Franco; Franza, Laura; Carusi, Valentina; Altamura, Simona; Andriollo, Gloria; Nucera, Eleonora.
  • Pandolfi F; Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
  • Franza L; Emergency Medicine, Fondazione Policlinico Universitario A, Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
  • Carusi V; Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
  • Altamura S; Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
  • Andriollo G; Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
  • Nucera E; Allergy and Clinical Immunology, Fondazione Policlinico Universitario A, Gemelli IRCCS, Catholic University, 00168 Rome, Italy.
Int J Mol Sci ; 21(15)2020 07 23.
Article in English | MEDLINE | ID: covidwho-670369
ABSTRACT
The role of interleukin (IL)-6 in health and disease has been under a lot of scrutiny in recent years, particularly during the recent COVID-19 pandemic. The inflammatory pathways in which IL-6 is involved are also partly responsible of the development and progression of rheumatoid arthritis (RA), opening interesting perspectives in terms of therapy. Anti-IL-6 drugs are being used with variable degrees of success in other diseases and are being tested in RA. Results have been encouraging, particularly when anti-IL-6 has been used with other drugs, such as metothrexate (MTX). In this review we discuss the main immunologic aspects that make anti-IL-6 a good candidate in RA, but despite the main therapeutic options available to target IL-6, no gold standard treatment has been established so far.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Interleukin-6 Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21155238

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Interleukin-6 Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21155238