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Adsorptive granulocyte and monocyte apheresis: A potentially relevant therapeutic option for COVID-19.
Kanekura, Takuro; Kawahara, Koichi.
  • Kanekura T; Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. Electronic address: takurok@m2.kufm.kagoshima-u.ac.jp.
  • Kawahara K; Laboratory of Functional Foods, Department of Biomedical Engineering, Osaka Institute of Technology, 5-16-1 Omiya, Asahi-ku, Osaka 535-8585, Japan.
Int J Infect Dis ; 99: 1-2, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-670708
ABSTRACT
The overproduction of proinflammatory cytokines and subsequent thromboembolism are major problems of coronavirus disease 2019 (COVID-19). Adsorptive granulocyte and monocyte apheresis (GMA), used for ulcerative colitis, is an extracorporeal therapy designed to remove activated myeloid lineage cells. Previous studies have demonstrated that GMA decreases proinflammatory cytokines and neutrophil-platelet aggregates. The effect of GMA on COVID-19 in a patient with ulcerative colitis was recently reported. The modes of action of GMA together with the findings of this case report indicate that GMA could be a relevant treatment option for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Component Removal / Monocytes / Coronavirus Infections / Betacoronavirus / Granulocytes Type of study: Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Component Removal / Monocytes / Coronavirus Infections / Betacoronavirus / Granulocytes Type of study: Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article