Plasma levels of soluble ACE2are associated with sex, Metabolic Syndrome, and its biomarkers in a large cohort, pointing to a possible mechanism for increased severity in COVID-19.

Kornilov, Sergey A; Lucas, Isabelle; Jade, Kathleen; Dai, Chengzhen L; Lovejoy, Jennifer C; Magis, Andrew T

Kornilov, Sergey A; Lucas, Isabelle; Jade, Kathleen; Dai, Chengzhen L; Lovejoy, Jennifer C; Magis, Andrew T.

Kornilov SA; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA. sergey.kornilov@isbscience.org.
Lucas I; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.
Jade K; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.
Dai CL; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.
Lovejoy JC; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.
Magis AT; Institute for Systems Biology, Seattle, WA 401 Terry Ave N, Seattle, WA, 98109-5263, USA.

Crit Care ; 24(1): 452, 2020 07 22.

Article in English | MEDLINE | ID: covidwho-670790

Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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Subject(s)

Coronavirus Infections/enzymology; Peptidyl-Dipeptidase A/blood; Pneumonia, Viral/enzymology; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme 2; Biomarkers/blood; COVID-19; Cohort Studies; Coronavirus Infections/mortality; Female; Humans; Male; Metabolic Syndrome/epidemiology; Middle Aged; Pandemics; Pneumonia, Viral/mortality; Severity of Illness Index; Sex Factors; Young Adult

Keywords

ACE2; COVID-19; GGT; Liver function; Metabolic syndrome; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03141-9

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