Could the antipsychotic chlorpromazine be a potential treatment for SARS-CoV-2?

Nobile, B; Durand, M; Courtet, P; Van de Perre, P; Nagot, N; Molès, J P; Olié, E

Nobile, B; Durand, M; Courtet, P; Van de Perre, P; Nagot, N; Molès, J P; Olié, E.

Nobile B; Department of Emergency Psychiatry and Acute Care, CHU Montpellier, France; PSNREC, Univ Montpellier, INSERM, CHU de Montpellier, Montpellier, France. Electronic address: benedicte.nobile@gmail.com.
Durand M; Pathogenesis and Control of Chronic Infection, INSERM, EFS, Université de Montpellier, Montpellier, France.
Courtet P; Department of Emergency Psychiatry and Acute Care, CHU Montpellier, France; PSNREC, Univ Montpellier, INSERM, CHU de Montpellier, Montpellier, France; FondaMental Foundation, France.
Van de Perre P; Pathogenesis and Control of Chronic Infection, INSERM, EFS, Université de Montpellier, Montpellier, France.
Nagot N; Pathogenesis and Control of Chronic Infection, INSERM, EFS, Université de Montpellier, Montpellier, France; Department of Medical Information, CHU Montpellier, France.
Molès JP; Pathogenesis and Control of Chronic Infection, INSERM, EFS, Université de Montpellier, Montpellier, France.
Olié E; Department of Emergency Psychiatry and Acute Care, CHU Montpellier, France; PSNREC, Univ Montpellier, INSERM, CHU de Montpellier, Montpellier, France; FondaMental Foundation, France.

Schizophr Res ; 223: 373-375, 2020 09.

Article in English | MEDLINE | ID: covidwho-671226

Subject(s)

Antipsychotic Agents/pharmacology; COVID-19 Drug Treatment; Chlorpromazine/pharmacology; Clathrin-Coated Vesicles/drug effects; Endocytosis/drug effects; Spike Glycoprotein, Coronavirus/drug effects; Virus Internalization/drug effects; Virus Replication/drug effects; Antipsychotic Agents/therapeutic use; Chlorpromazine/therapeutic use; Drug Repositioning; Humans; Hydrogen-Ion Concentration/drug effects; In Vitro Techniques

Keywords

Chlorpromazine; Clathrin-mediated endocytosis; SARS-CoV-2; Sedative medication; Viral replication

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antipsychotic Agents / Virus Replication / Chlorpromazine / Clathrin-Coated Vesicles / Endocytosis / Virus Internalization / Spike Glycoprotein, Coronavirus / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Schizophr Res Journal subject: Psychiatry Year: 2020 Document Type: Article

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