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Incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 patients: a systematic review and meta-analysis.
Wu, Yanyan; Li, Hongyu; Guo, Xiaozhong; Yoshida, Eric M; Mendez-Sanchez, Nahum; Levi Sandri, Giovanni Battista; Teschke, Rolf; Romeiro, Fernando Gomes; Shukla, Akash; Qi, Xingshun.
  • Wu Y; Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, People's Republic of China.
  • Li H; Postgraduate College, Jinzhou Medical University, Jinzhou, People's Republic of China.
  • Guo X; Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, People's Republic of China.
  • Yoshida EM; Liver Cirrhosis Study Group, Department of Gastroenterology, General Hospital of Northern Theater Command (formerly called General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, 110840, Liaoning Province, People's Republic of China.
  • Mendez-Sanchez N; Division of Gastroenterology, Vancouver General Hospital, Vancouver, Canada.
  • Levi Sandri GB; Liver Research Unit Medica Sur Clinic and Foundation and Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
  • Teschke R; Department of Surgical Sciences, Sapienza University of Rome, 00161, Rome, Italy.
  • Romeiro FG; Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, Hanau, Germany.
  • Shukla A; Faculdade de Medicina de Botucatu, UNESP, Campus de Botucatu, Botucatu, Brazil.
  • Qi X; Department of Gastroenterology, Seth G S Medical College and K E M Hospital, Parel, Mumbai, India.
Hepatol Int ; 14(5): 621-637, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-671930
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. liver test abnormal PROCESS_OF Patients
Subject
liver test abnormal
Predicate
PROCESS_OF
Object
Patients
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
4. liver test abnormal PROCESS_OF Patients
Subject
liver test abnormal
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
BACKGROUND AND

AIMS:

Coronavirus disease 2019 (COVID-19) pandemic is ongoing. Except for lung injury, it is possible that COVID-19 patients develop liver injury. Thus, we conducted a systematic review and meta-analysis to explore the incidence, risk factors, and prognosis of abnormal liver biochemical tests in COVID-19 patients.

METHODS:

PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases were searched. The incidence of abnormal liver biochemical tests, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), total bilirubin (TBIL), and albumin (ALB), was pooled. Risk ratio (RR) was calculated to explore the association of abnormal liver biochemical tests with severity and prognosis of COVID-19 patients.

RESULTS:

Forty-five studies were included. The pooled incidence of any abnormal liver biochemical indicator at admission and during hospitalization was 27.2% and 36%, respectively. Among the abnormal liver biochemical indicators observed at admission, abnormal ALB was the most common, followed by GGT, AST, ALT, TBIL, and ALP (39.8%, 35.8%, 21.8%, 20.4%, 8.8%, and 4.7%). Among the abnormal liver biochemical indicators observed during hospitalization, abnormal ALT was more common than AST and TBIL (38.4%, 28.1%, and 23.2%). Severe and/or critical patients had a significantly higher pooled incidence of abnormal liver biochemical indicators at admission than mild and/or moderate patients. Non-survivors had a significantly higher incidence of abnormal liver biochemical indicators than survivors (RR = 1.34, p = 0.04).

CONCLUSIONS:

Abnormal liver biochemical tests are common in COVID-19 patients. Liver biochemical indicators are closely related to the severity and prognosis of COVID-19 patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Critical Care / Hepatic Insufficiency / Pandemics / Liver Function Tests Type of study: Diagnostic study / Etiology study / Incidence study / Prognostic study / Reviews / Risk factors / Systematic review Limits: Humans Language: English Journal: Hepatol Int Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Critical Care / Hepatic Insufficiency / Pandemics / Liver Function Tests Type of study: Diagnostic study / Etiology study / Incidence study / Prognostic study / Reviews / Risk factors / Systematic review Limits: Humans Language: English Journal: Hepatol Int Year: 2020 Document Type: Article