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Evolution and epidemic spread of SARS-CoV-2 in Brazil.
Candido, Darlan S; Claro, Ingra M; de Jesus, Jaqueline G; Souza, William M; Moreira, Filipe R R; Dellicour, Simon; Mellan, Thomas A; du Plessis, Louis; Pereira, Rafael H M; Sales, Flavia C S; Manuli, Erika R; Thézé, Julien; Almeida, Luiz; Menezes, Mariane T; Voloch, Carolina M; Fumagalli, Marcilio J; Coletti, Thaís M; da Silva, Camila A M; Ramundo, Mariana S; Amorim, Mariene R; Hoeltgebaum, Henrique H; Mishra, Swapnil; Gill, Mandev S; Carvalho, Luiz M; Buss, Lewis F; Prete, Carlos A; Ashworth, Jordan; Nakaya, Helder I; Peixoto, Pedro S; Brady, Oliver J; Nicholls, Samuel M; Tanuri, Amilcar; Rossi, Átila D; Braga, Carlos K V; Gerber, Alexandra L; de C Guimarães, Ana Paula; Gaburo, Nelson; Alencar, Cecila Salete; Ferreira, Alessandro C S; Lima, Cristiano X; Levi, José Eduardo; Granato, Celso; Ferreira, Giulia M; Francisco, Ronaldo S; Granja, Fabiana; Garcia, Marcia T; Moretti, Maria Luiza; Perroud, Mauricio W; Castiñeiras, Terezinha M P P; Lazari, Carolina S.
  • Candido DS; Department of Zoology, University of Oxford, Oxford, UK.
  • Claro IM; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • de Jesus JG; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Souza WM; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Moreira FRR; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Dellicour S; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Mellan TA; Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil.
  • du Plessis L; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Pereira RHM; Spatial Epidemiology Lab, Université Libre de Bruxelles, Brussels, Belgium.
  • Sales FCS; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Manuli ER; MRC Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London, UK.
  • Thézé J; Department of Zoology, University of Oxford, Oxford, UK.
  • Almeida L; Institute for Applied Economic Research, Brasília, Brazil.
  • Menezes MT; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Voloch CM; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Fumagalli MJ; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Coletti TM; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • da Silva CAM; Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Saint-Genès-Champanelle, France.
  • Ramundo MS; Laboratório de Bioinformática, Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
  • Amorim MR; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Hoeltgebaum HH; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Mishra S; Centro de Pesquisa em Virologia, Faculdade de Medicina de Ribeirão Preto, Ribeirão Preto, Brazil.
  • Gill MS; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Carvalho LM; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Buss LF; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Prete CA; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Ashworth J; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Nakaya HI; Departamento de Moléstias Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Peixoto PS; Departamento de Genética, Evolução, Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil.
  • Brady OJ; Department of Mathematics, Imperial College London, London, UK.
  • Nicholls SM; MRC Centre for Global Infectious Disease Analysis, J-IDEA, Imperial College London, London, UK.
  • Tanuri A; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
  • Rossi ÁD; Escola de Matemática Aplicada (EMAp), Fundação Getúlio Vargas, Rio de Janeiro, Brazil.
  • Braga CKV; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Gerber AL; Department of Electronic Systems Engineering, University of São Paulo, São Paulo, Brazil.
  • de C Guimarães AP; Usher Institute, University of Edinburgh, Edinburgh, UK.
  • Gaburo N; Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil.
  • Alencar CS; Departamento de Matemática Aplicada, Instituto de Matemática e Estatística, Universidade de São Paulo, São Paulo, Brazil.
  • Ferreira ACS; Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
  • Lima CX; Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.
  • Levi JE; Institute for Microbiology and Infection, University of Birmingham, Birmingham, UK.
  • Granato C; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Ferreira GM; Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Francisco RS; Institute for Applied Economic Research, Brasília, Brazil.
  • Granja F; Laboratório de Bioinformática, Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
  • Garcia MT; Laboratório de Bioinformática, Laboratório Nacional de Computação Científica, Petrópolis, Brazil.
  • Moretti ML; DB Diagnósticos do Brasil, São Paulo, Brazil.
  • Perroud MW; LIM 03 Laboratório de Medicina Laboratorial, Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
  • Castiñeiras TMPP; Instituto Hermes Pardini, Belo Horizonte, Brazil.
  • Lazari CS; Departamento de Cirurgia, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Science ; 369(6508): 1255-1260, 2020 09 04.
Article in English | MEDLINE | ID: covidwho-675945
Semantic information from SemMedBD (by NLM)
1. Virus LOCATION_OF IMPACT gene
Subject
Virus
Predicate
LOCATION_OF
Object
IMPACT gene
2. Virus LOCATION_OF IMPACT gene
Subject
Virus
Predicate
LOCATION_OF
Object
IMPACT gene
ABSTRACT
Brazil currently has one of the fastest-growing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemics in the world. Because of limited available data, assessments of the impact of nonpharmaceutical interventions (NPIs) on this virus spread remain challenging. Using a mobility-driven transmission model, we show that NPIs reduced the reproduction number from >3 to 1 to 1.6 in São Paulo and Rio de Janeiro. Sequencing of 427 new genomes and analysis of a geographically representative genomic dataset identified >100 international virus introductions in Brazil. We estimate that most (76%) of the Brazilian strains fell in three clades that were introduced from Europe between 22 February and 11 March 2020. During the early epidemic phase, we found that SARS-CoV-2 spread mostly locally and within state borders. After this period, despite sharp decreases in air travel, we estimated multiple exportations from large urban centers that coincided with a 25% increase in average traveled distances in national flights. This study sheds new light on the epidemic transmission and evolutionary trajectories of SARS-CoV-2 lineages in Brazil and provides evidence that current interventions remain insufficient to keep virus transmission under control in this country.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Randomized controlled trials / Risk factors Limits: Humans Country/Region as subject: South America / Brazil / Europa Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abd2161

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Randomized controlled trials / Risk factors Limits: Humans Country/Region as subject: South America / Brazil / Europa Language: English Journal: Science Year: 2020 Document Type: Article Affiliation country: Science.abd2161