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Coagulation Status and Venous Thromboembolism Risk in African Americans: A Potential Risk Factor in COVID-19.
Frydman, Galit H; Boyer, Edward W; Nazarian, Rosalynn M; Van Cott, Elizabeth M; Piazza, Gregory.
  • Frydman GH; Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.
  • Boyer EW; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Nazarian RM; Department of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Van Cott EM; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  • Piazza G; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
Clin Appl Thromb Hemost ; 26: 1076029620943671, 2020.
Article in English | MEDLINE | ID: covidwho-676150
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 infection (COVID-19) is known to induce severe inflammation and activation of the coagulation system, resulting in a prothrombotic state. Although inflammatory conditions and organ-specific diseases have been shown to be strong determinants of morbidity and mortality in patients with COVID-19, it is unclear whether preexisting differences in coagulation impact the severity of COVID-19. African Americans have higher rates of COVID-19 infection and disease-related morbidity and mortality. Moreover, African Americans are known to be at a higher risk for thrombotic events due to both biological and socioeconomic factors. In this review, we explore whether differences in baseline coagulation status and medical management of coagulation play an important role in COVID-19 disease severity and contribute to racial disparity trends within COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Black or African American / Coronavirus Infections / Thrombophilia / Venous Thromboembolism / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: 1076029620943671

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Black or African American / Coronavirus Infections / Thrombophilia / Venous Thromboembolism / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: 1076029620943671