Chinese medical drugs for coronavirus disease 2019: A systematic review and meta-analysis.
Integr Med Res
; 9(3): 100477, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-676559
ABSTRACT
BACKGROUND:
Integration of Chinese medical drugs (CMD) and western medicine (WM) has been widely used in the treatment of Coronavirus Disease 2019 (COVID-19). This systematic review aimed to evaluate the efficacy and safety of CMD for COVID-19.METHOD:
A literature search was performed in six databases from injection to June 2020. Both randomized controlled trials (RCTs) and quasi-RCTs were considered as eligible. The quality of included RCTs were assessed by Cochrane Risk of Bias Tool, and Review Manager 5.3 software was used to do meta-analysis.RESULT:
Eleven studies with 1259 patients were included in this study. CMD included herbal decoction and Chinese patent medicine. The methodological quality was evaluated as generally unclear. The results of meta-analysis showed that the integration of CMD and WM had better efficacy than WM in number of patients turned to severe and critical type (RRâ¯=â¯0.47, 95% CI=[0.32, 0.69], Pâ¯<â¯0.0001), length of hospital stay (MD= -7.95, 95% CI=[-14.66, -1.24], Pâ¯=â¯0.02), defervescence time (MD= -1.20, 95% CI=[-2.03, -0.38], Pâ¯=â¯0.004), cough resolution rate (RRâ¯=â¯1.37, 95% CI=[1.15, 1.64], Pâ¯=â¯0.0004), fatigue resolution rate (RRâ¯=â¯1.37, 95% CI=[1.02, 1.83], Pâ¯=â¯0.04), and tachypnea resolution rate (RRâ¯=â¯2.20, 95% CI=[1.11, 4.39], Pâ¯=â¯0.02). As for safety, there was no significant difference between two groups.CONCLUSION:
CMD may bring potential benefit to patients suffered from COVID-19. However, the quality of included trials is not good enough. High quality study with core outcome set are still required.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
/
Systematic review/Meta Analysis
Topics:
Traditional medicine
Language:
English
Journal:
Integr Med Res
Year:
2020
Document Type:
Article
Affiliation country:
J.imr.2020.100477
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