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Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis.
Wilson, Jennifer G; Simpson, Laura J; Ferreira, Anne-Maud; Rustagi, Arjun; Roque, Jonasel; Asuni, Adijat; Ranganath, Thanmayi; Grant, Philip M; Subramanian, Aruna; Rosenberg-Hasson, Yael; Maecker, Holden T; Holmes, Susan P; Levitt, Joseph E; Blish, Catherine A; Rogers, Angela J.
  • Wilson JG; Department of Emergency Medicine and.
  • Simpson LJ; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Ferreira AM; Department of Statistics, Stanford University, California, USA.
  • Rustagi A; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Roque J; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Asuni A; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Ranganath T; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Grant PM; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Subramanian A; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Rosenberg-Hasson Y; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.
  • Maecker HT; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.
  • Holmes SP; Department of Statistics, Stanford University, California, USA.
  • Levitt JE; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Blish CA; Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
  • Rogers AJ; Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.
JCI Insight ; 5(17)2020 09 03.
Article in English | MEDLINE | ID: covidwho-676865
Preprint
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Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
2. Poor outcome PROCESS_OF Patients
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Poor outcome
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PROCESS_OF
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Patients
3. Critical Illness PROCESS_OF Patients
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Critical Illness
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PROCESS_OF
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Patients
4. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
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PROCESS_OF
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C0030705
5. Septicemia PROCESS_OF Patients
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Septicemia
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PROCESS_OF
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Patients
6. COVID-19 PROCESS_OF hospitalized patients
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COVID-19
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PROCESS_OF
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hospitalized patients
7. Plasma LOCATION_OF cytokine
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Plasma
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LOCATION_OF
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cytokine
8. Plasma PART_OF hospitalized patients
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Plasma
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hospitalized patients
9. cytokine ASSOCIATED_WITH Storm NOS
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cytokine
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Storm NOS
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Subject
Respiratory Distress Syndrom
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PROCESS_OF
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C0599755
11. Septicemia PROCESS_OF Cohort
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Septicemia
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PROCESS_OF
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Cohort
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Therapeutic procedure
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TREATS
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COVID-19
13. Therapeutic immunosuppression TREATS Respiratory Distress Syndrom
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Therapeutic immunosuppression
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TREATS
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Respiratory Distress Syndrom
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Therapeutic procedure
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TREATS
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Patients
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COVID-19
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PROCESS_OF
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Patients
16. Poor outcome PROCESS_OF Patients
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Poor outcome
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PROCESS_OF
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Patients
17. Critical Illness PROCESS_OF Patients
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Critical Illness
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PROCESS_OF
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Patients
18. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
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Respiratory Distress Syndrome, Adult
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PROCESS_OF
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Patients
19. Septicemia PROCESS_OF Patients
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Septicemia
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PROCESS_OF
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Patients
20. COVID-19 PROCESS_OF hospitalized patients
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COVID-19
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PROCESS_OF
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hospitalized patients
21. Plasma LOCATION_OF cytokine
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Plasma
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LOCATION_OF
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cytokine
22. Plasma PART_OF hospitalized patients
Subject
Plasma
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PART_OF
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hospitalized patients
23. cytokine ASSOCIATED_WITH Storm NOS
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cytokine
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ASSOCIATED_WITH
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Storm NOS
24. Respiratory Distress Syndrome, Adult PROCESS_OF Cohort
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Respiratory Distress Syndrome, Adult
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Cohort
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Septicemia
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Cohort
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Therapeutic procedure
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TREATS
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COVID-19
27. Therapeutic immunosuppression TREATS Respiratory Distress Syndrome, Adult
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Therapeutic immunosuppression
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TREATS
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Respiratory Distress Syndrome, Adult
28. Therapeutic procedure TREATS Patients
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Therapeutic procedure
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TREATS
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Patients
ABSTRACT
BACKGROUNDElevated levels of inflammatory cytokines have been associated with poor outcomes among COVID-19 patients. It is unknown, however, how these levels compare with those observed in critically ill patients with acute respiratory distress syndrome (ARDS) or sepsis due to other causes.METHODSWe used a Luminex assay to determine expression of 76 cytokines from plasma of hospitalized COVID-19 patients and banked plasma samples from ARDS and sepsis patients. Our analysis focused on detecting statistical differences in levels of 6 cytokines associated with cytokine storm (IL-1ß, IL-1RA, IL-6, IL-8, IL-18, and TNF-α) between patients with moderate COVID-19, severe COVID-19, and ARDS or sepsis.RESULTSFifteen hospitalized COVID-19 patients, 9 of whom were critically ill, were compared with critically ill patients with ARDS (n = 12) or sepsis (n = 16). There were no statistically significant differences in baseline levels of IL-1ß, IL-1RA, IL-6, IL-8, IL-18, and TNF-α between patients with COVID-19 and critically ill controls with ARDS or sepsis.CONCLUSIONLevels of inflammatory cytokines were not higher in severe COVID-19 patients than in moderate COVID-19 or critically ill patients with ARDS or sepsis in this small cohort. Broad use of immunosuppressive therapies in ARDS has failed in numerous Phase 3 studies; use of these therapies in unselected patients with COVID-19 may be unwarranted.FUNDINGFunding was received from NHLBI K23 HL125663 (AJR); The Bill and Melinda Gates Foundation OPP1113682 (AJR and CAB); Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Diseases #1016687 NIH/NIAID U19AI057229-16; Stanford Maternal Child Health Research Institute; and Chan Zuckerberg Biohub (CAB).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Cytokines / Coronavirus Infections / Sepsis / Cytokine Release Syndrome Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Respiratory Distress Syndrome / Cytokines / Coronavirus Infections / Sepsis / Cytokine Release Syndrome Type of study: Observational study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article