Fragile Endothelium and Brain Dysregulated Neurochemical Activity in COVID-19.
ACS Chem Neurosci
; 11(15): 2159-2162, 2020 08 05.
Article
in English
| MEDLINE | ID: covidwho-677409
ABSTRACT
Immune system and renin-angiotensin-aldosterone system dysregulation with associated cytokine release syndrome may be a key feature of early stage of SARS-CoV-2 organotropism and infection. Following viral mediated brain injury, dysregulated neurochemical activity may cause neurogenic stress cardiomyopathy, which is characterized by transient myocardial dysfunction and arrhythmias. Cardiomyopathy along with acute acute inflammatory thromboembolism and endotheliitis (fragile endothelium) might at least partially explain the underlying mechanisms of rapidly evolving life-threatening COVID-19. Further studies are clearly required to explore these complex pathologies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Brain
/
Brain Chemistry
/
Endothelium, Vascular
/
Coronavirus Infections
/
Betacoronavirus
Limits:
Animals
/
Humans
Language:
English
Journal:
ACS Chem Neurosci
Year:
2020
Document Type:
Article
Affiliation country:
Acschemneuro.0c00437
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