Comprehensive analysis of drugs to treat SARSCoV2 infection: Mechanistic insights into current COVID19 therapies (Review).
Int J Mol Med
; 46(2): 467-488, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-678269
ABSTRACT
The major impact produced by the severe acute respiratory syndrome coronavirus 2 (SARSCoV2) focused many researchers attention to find treatments that can suppress transmission or ameliorate the disease. Despite the very fast and large flow of scientific data on possible treatment solutions, none have yet demonstrated unequivocal clinical utility against coronavirus disease 2019 (COVID19). This work represents an exhaustive and critical review of all available data on potential treatments for COVID19, highlighting their mechanistic characteristics and the strategy development rationale. Drug repurposing, also known as drug repositioning, and target based methods are the most used strategies to advance therapeutic solutions into clinical practice. Current in silico, in vitro and in vivo evidence regarding proposed treatments are summarized providing strong support for future research efforts.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Virus Internalization
/
Drug Repositioning
/
Betacoronavirus
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Language:
English
Journal:
Int J Mol Med
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2020
Document Type:
Article
Affiliation country:
Ijmm.2020.4608
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