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Guillain-Barré syndrome associated with leptomeningeal enhancement following SARS-CoV-2 infection.
Sancho-Saldaña, Agustín; Lambea-Gil, Álvaro; Liesa, Jose Luis Capablo; Caballo, Maria Rosario Barrena; Garay, Maria Haddad; Celada, David Rivero; Serrano-Ponz, Marta.
  • Sancho-Saldaña A; Hospital Universitario Miguel Servet, Zaragoza, Spain agustinsanchosaldana@gmail.com.
  • Lambea-Gil Á; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Liesa JLC; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Caballo MRB; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Garay MH; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Celada DR; Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Serrano-Ponz M; Hospital Universitario Miguel Servet, Zaragoza, Spain.
Clin Med (Lond) ; 20(4): e93-e94, 2020 07.
Article in English | MEDLINE | ID: covidwho-679736
ABSTRACT

INTRODUCTION:

Patients with coronavirus disease 2019 (COVID-19) typically present with respiratory symptoms, but little is known about the disease's potential neurological complications.We report a case of Guillain-Barré syndrome (GBS) following a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, in association with leptomeningeal enhancement. CASE PRESENTATION A 56-year-old woman presented with recent unsteadiness and paraesthesia in both hands. Fifteen days earlier, she complained of fever, dry cough and shortness of breath. Her chest X-ray showed a lobar consolidation and PCR was positive for SARS-CoV-2; she was admitted due to mild COVID-19 pneumonia.In the first 48 hours of hospitalisation, she started to experience lumbar pain and weakness of the proximal lower extremities, progressing to bilateral facial nerve palsy, oropharyngeal weakness and severe proximal tetraparesis with cervical flexion 2/5 on the MRC scale. Full spine magnetic resonance imaging (MRI) showed a brainstem and cervical leptomeningeal enhancement. Analysis of cerebrospinal fluid (CSF) revealed albumin-cytological dissociation. Microbiological studies on CSF, including SARS-CoV-2, were negative. Nerve conduction studies were consistent with demyelinating neuropathy. She was treated with intravenous immunoglobulin, with significant neurological improvement noted over the next 2 weeks.

CONCLUSION:

Leptomeningeal enhancement is an atypical feature in GBS, but could be a marker of its association with SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Guillain-Barre Syndrome / Betacoronavirus Type of study: Case report Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article Affiliation country: Clinmed.2020-0213

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Guillain-Barre Syndrome / Betacoronavirus Type of study: Case report Topics: Long Covid Limits: Female / Humans / Middle aged Language: English Journal: Clin Med (Lond) Year: 2020 Document Type: Article Affiliation country: Clinmed.2020-0213