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Contribution of acute-phase reaction proteins to the diagnosis and treatment of 2019 novel coronavirus disease (COVID-19).
Li, Lu; Chen, Changzheng.
  • Li L; Department of Ophthalmology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province, 430060, People's Republic of China.
  • Chen C; Department of Ophthalmology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, Hubei Province, 430060, People's Republic of China.
Epidemiol Infect ; 148: e164, 2020 07 27.
Article in English | MEDLINE | ID: covidwho-679966
Semantic information from SemMedBD (by NLM)
1. Community acquired pneumonia PROCESS_OF Patients
Subject
Community acquired pneumonia
Predicate
PROCESS_OF
Object
Patients
2. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
3. Community acquired pneumonia COEXISTS_WITH Coronaviridae
Subject
Community acquired pneumonia
Predicate
COEXISTS_WITH
Object
Coronaviridae
4. C-reactive protein compared_with SAA1 gene|SAA1
Subject
C-reactive protein
Predicate
compared_with
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SAA1 gene|SAA1
5. Asymptomatic COMPLICATES Disease
Subject
Asymptomatic
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COMPLICATES
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Disease
6. Disease PROCESS_OF Patients
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Disease
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PROCESS_OF
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Patients
7. Community acquired pneumonia PROCESS_OF Patients
Subject
Community acquired pneumonia
Predicate
PROCESS_OF
Object
Patients
8. Borg Category-Ratio 10 Perceived Exertion Score 5 PROCESS_OF Patients
Subject
Borg Category-Ratio 10 Perceived Exertion Score 5
Predicate
PROCESS_OF
Object
Patients
9. Community acquired pneumonia COEXISTS_WITH Coronaviridae
Subject
Community acquired pneumonia
Predicate
COEXISTS_WITH
Object
Coronaviridae
10. C-reactive protein compared_with SAA1 gene|SAA1
Subject
C-reactive protein
Predicate
compared_with
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SAA1 gene|SAA1
11. Asymptomatic COMPLICATES Disease
Subject
Asymptomatic
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COMPLICATES
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Disease
12. Disease PROCESS_OF Patients
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Disease
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PROCESS_OF
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Patients
ABSTRACT
The emergence of 2019 novel coronavirus disease (COVID-19) is currently a global concern. In this study, our goal was to explore the changing expression levels of acute-phase reaction proteins (APRPs) in the serum of COVID-19 patients and to elucidate the immunological characteristics of COVID-19. In the study design, we recruited 72 COVID-19 patients, including 22 cases of mild degree, 38 cases of moderate degree and 12 cases of severe degree. We also recruited 20 patients with community-acquired pneumonia (CAP) and 20 normal control subjects as a comparison. Fasting venous blood was taken to detect the content of complement 3 (C3), complement 4 (C4), C-reactive protein (CRP), serum amyloid A (SAA) and prealbumin (PA). When compared the COVID-19 group with the CAP and normal control groups, respectively, the mean value of CRP and SAA in the COVID-19 group (including mild, moderate and severe patients) had increased significantly (P < 0.01), whereas the mean values of C3, C4 and PA decreased (P < 0.01). For the asymptomatic or mild symptomatic patients with COVID-19, the actual aggravation of disease may be more advanced than the clinical appearances. Meanwhile, the statistical analyses indicated that the development of COVID-19 brought about a significant increase in the content of CRP and SAA (P < 0.01), and a decline in the content of C3, C4 and PA (P < 0.01). These findings suggested that the changes in the level of APRPs could be used as indicators to identify the degree and progression of COVID-19, and the significant changes might demonstrate the aggravation of disease. This study provided a new approach to improve the clinical management plan and prognosis of COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Acute-Phase Proteins / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Acute-Phase Proteins / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article