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Pattern of comorbidities and 1-year mortality in elderly patients with COPD hospitalized in internal medicine wards: data from the RePoSI Registry.
Argano, Christiano; Scichilone, Nicola; Natoli, Giuseppe; Nobili, Alessandro; Corazza, Gino Roberto; Mannucci, Pier Mannuccio; Perticone, Francesco; Corrao, Salvatore.
  • Argano C; Internal Medicine Department, UOC Medicina Interna iGR, National Relevance Hospital Trust, ARNAS Civico, Di Cristina e Benfratelli, Piazza Nicola Leotta, 2, 90127, Palermo, Italy.
  • Scichilone N; Dipartimento di Promozione della Salute, Materno Infantile, Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro, University of Palermo, Palermo, Italy.
  • Natoli G; Internal Medicine Department, UOC Medicina Interna iGR, National Relevance Hospital Trust, ARNAS Civico, Di Cristina e Benfratelli, Piazza Nicola Leotta, 2, 90127, Palermo, Italy.
  • Nobili A; Department of Neuroscience, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
  • Corazza GR; Department of Internal Medicine, University of Pavia and San Matteo Hospital, Pavia, Italy.
  • Mannucci PM; Scientific Direction, IRCCS Foundation Maggiore Hospital Policlinico, Milan, Italy.
  • Perticone F; Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy.
  • Corrao S; Internal Medicine Department, UOC Medicina Interna iGR, National Relevance Hospital Trust, ARNAS Civico, Di Cristina e Benfratelli, Piazza Nicola Leotta, 2, 90127, Palermo, Italy. salvatore.corrao@unipa.it.
Intern Emerg Med ; 16(2): 389-400, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-680151
ABSTRACT
Currently, chronic obstructive pulmonary disease (COPD) represents the fourth cause of death worldwide with significant economic burden. Comorbidities increase in number and severity with age and are identified as important determinants that influence the prognosis. In this observational study, we retrospectively analyzed data collected from the RePoSI register. We aimed to investigate comorbidities and outcomes in a cohort of hospitalized elderly patients with the clinical diagnosis of COPD. Socio-demographic, clinical characteristics and laboratory findings were considered. The association between variables and in-hospital, 3-month and 1-year follow-up were analyzed. Among 4696 in-patients, 932 (19.8%) had a diagnosis of COPD. Patients with COPD had more hospitalization, a significant overt cognitive impairment, a clinically significant disability and more depression in comparison with non-COPD subjects. COPD patients took more drugs, both at admission, in-hospital stay, discharge and 3-month and 1-year follow-up. 14 comorbidities were more frequent in COPD patients. Cerebrovascular disease was an independent predictor of in-hospital mortality. At 3-month follow-up, male sex and hepatic cirrhosis were independently associated with mortality. ICS-LABA therapy was predictor of mortality at in-hospital, 3-month and 1-year follow-up. This analysis showed the severity of impact of COPD and its comorbidities in the real life of internal medicine and geriatric wards.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Pulmonary Disease, Chronic Obstructive Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Intern Emerg Med Journal subject: Emergency Medicine / Internal Medicine Year: 2021 Document Type: Article Affiliation country: S11739-020-02412-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Hospital Mortality / Pulmonary Disease, Chronic Obstructive Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male Language: English Journal: Intern Emerg Med Journal subject: Emergency Medicine / Internal Medicine Year: 2021 Document Type: Article Affiliation country: S11739-020-02412-1