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More than just a common cold: Endemic coronaviruses OC43, HKU1, NL63, and 229E associated with severe acute respiratory infection and fatality cases among healthy adults.
Veiga, Ana B Gorini da; Martins, Letícia G; Riediger, Irina; Mazetto, Alix; Debur, Maria do Carmo; Gregianini, Tatiana S.
  • Veiga ABGD; Department of Basic Health Sciences, Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Porto Alegre, Rio Grande do Sul, Brazil.
  • Martins LG; Centro Estadual de Vigilância em Saúde da Secretaria de Saúde do Estado do Rio Grande do Sul (CEVS/SES-RS), Porto Alegre, Rio Grande do Sul, Brazil.
  • Riediger I; Laboratório Central de Saúde Pública da Secretaria de Saúde do Estado do Paraná (LACEN-PR), São José dos Pinhais, Paraná, Brazil.
  • Mazetto A; Laboratório Central de Saúde Pública da Secretaria de Saúde do Estado do Paraná (LACEN-PR), São José dos Pinhais, Paraná, Brazil.
  • Debur MDC; Laboratório Central de Saúde Pública da Secretaria de Saúde do Estado do Paraná (LACEN-PR), São José dos Pinhais, Paraná, Brazil.
  • Gregianini TS; Laboratório Central de Saúde Pública da Secretaria de Saúde do Estado do Rio Grande do Sul (LACEN-RS), Porto Alegre, Rio Grande do Sul, Brazil.
J Med Virol ; 93(2): 1002-1007, 2021 02.
Article in English | MEDLINE | ID: covidwho-1196430
ABSTRACT
Respiratory viral infection can cause severe disease and hospitalization, especially among children, the elderly, and patients with comorbidities. In Brazil, the official surveillance system of severe acute respiratory infection (SARI) investigates influenza A (IAV) and B (IBV) viruses, respiratory syncytial virus (RSV), adenovirus (HAdV), and parainfluenza viruses (hPIV 1-3). In Rio Grande do Sul (RS), Brazil, many fatalities associated with SARI between 2013 and 2017 occurred among patients without underlying diseases and for whom the causative agent had not been identified using official protocols. This cross-sectional study analyzed the presence of coronaviruses (HCoV), bocavirus (HBoV), metapneumovirus (hMPV), and rhinovirus in patients who died of SARI despite not having comorbidities, and that were negative for IAV, IBV, RSV, HAdV, and hPIV. Nasopharyngeal aspirates/swabs from patients were used for nucleic acid extraction. The presence of HCoVs OC43, HKU1, NL63, and 229E; HBoV; hMPV; and rhinovirus was assessed by quantitative reverse transcription-polymerase chain reaction. Clinical data were also analyzed. Between 2013 and 2017, 16 225 cases of SARI were reported in RS; 9.8% of the patients died; 20% of all fatal cases were patients without comorbidities and for whom no pathogen was detected using standard protocols. Analysis of 271 of these cases identified HCoV in nine cases; HBoV, hMPV, and rhinovirus were detected in 3, 3, and 10 cases, respectively. Of note, patients infected with HCoV were adults. Results reinforce the importance of including coronaviruses in diagnostic panels used by official surveillance systems because besides their pandemic potential, endemic HCoVs are associated to severe disease in healthy adults.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus OC43, Human / Coronavirus NL63, Human Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26362

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronavirus Infections / Coronavirus OC43, Human / Coronavirus NL63, Human Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: South America / Brazil Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.26362