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Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study.
Cui, Xiaoyang; Yu, Xin; Wu, Xiaojing; Huang, Linna; Tian, Ye; Huang, Xu; Zhang, Zeyu; Cheng, Zhenshun; Guo, Qiang; Zhang, Yi; Cai, Ying; Zhan, Qingyuan.
  • Cui X; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Yu X; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Wu X; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Huang L; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Tian Y; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Huang X; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Zhang Z; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Cheng Z; Department of Pulmonary and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
  • Guo Q; Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
  • Zhang Y; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Cai Y; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.
  • Zhan Q; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China, drzhanqy@163.com.
Kidney Blood Press Res ; 45(4): 612-622, 2020.
Article in English | MEDLINE | ID: covidwho-680430
Semantic information from SemMedBD (by NLM)
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PROCESS_OF
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2. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
3. Single organ dysfunction COEXISTS_WITH Severe acute respiratory infection
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Severe acute respiratory infection
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Sequential Organ Failure Assessment Scores
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PREDISPOSES
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Kidney Failur
9. Kidney Failure, Acute PROCESS_OF Patients
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Kidney Failure, Acute
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COVID-19
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Patients
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Severe acute respiratory infection
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LOCATION_OF
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Severely Abnormal Ventricular Ejection Fraction
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Severely Abnormal Ventricular Ejection Fraction
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Patients
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PREDISPOSES
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Kidney Failure, Acute
ABSTRACT

INTRODUCTION:

Severe acute respiratory viral infections are frequency accompanied by multiple organ dysfunction, including acute kidney injury (AKI). In December 2019, the coronavirus disease 2019 (COVID-19) outbreak began in Wuhan, Hubei Province, China, and rapidly spread worldwide. While diffuse alveolar damage and acute respiratory failure are the main features of COVID-19, other organs may be involved, and the incidence of AKI is not well described. We assessed the incidence and clinical characteristics of AKI in patients with laboratory-confirmed COVID-19 and its effects on clinical outcomes.

METHODS:

We conducted a multicenter, retrospective, observational study of patients with COVID-19 admitted to two general hospitals in Wuhan from 5 January 2020 to 21 March 2020. Demographic data and information on organ dysfunction were collected daily. AKI was defined according to the KDIGO clinical practice guidelines. Early and late AKI were defined as AKI occurring within 72 h after admission or after 72 h, respectively.

RESULTS:

Of the 116 patients, AKI developed in 21 (18.1%) patients. Among them, early and late AKI were found in 13 (11.2%) and 8 (6.9%) patients, respectively. Compared with patients without AKI, patients with AKI had more severe organ dysfunction, as indicated by a higher level of disease severity status, higher sequential organ failure assessment (SOFA) score on admission, an increased prevalence of shock, and a higher level of respiratory support. Patients with AKI had a higher SOFA score on admission (4.5 ± 2.1 vs. 2.8 ± 1.4, OR 1.498, 95% CI 1.047-2.143 ) and greater hospital mortality (57.1% vs. 12.6%, OR 3.998, 95% CI 1.088-14.613) than patients without AKI in both the univariate and multivariate analyses. Patients with late AKI, but not those with early AKI, had a significantly prolonged length of stay (19.6 vs. 9.6 days, p = 0.015).

CONCLUSION:

Our findings show that admission SOFA score was an independent risk factor for AKI in COVID-19 patients, and patients with AKI had higher in-hospital mortality. Moreover, AKI development after 72 h of admission was related to prolonged hospitalization time.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Acute Kidney Injury Type of study: Controlled clinical trial / Etiology study / Clinical Practice Guide / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Kidney Blood Press Res Journal subject: Nephrology Year: 2020 Document Type: Article Affiliation country: 000509517

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Acute Kidney Injury Type of study: Controlled clinical trial / Etiology study / Clinical Practice Guide / Incidence study / Observational study / Prognostic study / Risk factors Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Kidney Blood Press Res Journal subject: Nephrology Year: 2020 Document Type: Article Affiliation country: 000509517