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Neuroinvasion, neurotropic, and neuroinflammatory events of SARS-CoV-2: understanding the neurological manifestations in COVID-19 patients.
Yachou, Yassine; El Idrissi, Abdeslem; Belapasov, Vladimir; Ait Benali, Said.
  • Yachou Y; Neurology Department, Astrakhan State Medical University, Astrakhan, Russia. Yassine.yachou@gmail.com.
  • El Idrissi A; Center for Developmental Neuroscience, City University of New York, College of Staten Island, New York, USA.
  • Belapasov V; Neurology Department, Astrakhan State Medical University, Astrakhan, Russia.
  • Ait Benali S; Neurosurgery Department, Mohammed VI University Hospital Center, Cadi Ayyad University, Marrakech, Morocco.
Neurol Sci ; 41(10): 2657-2669, 2020 Oct.
Статья в английский | MEDLINE | ID: covidwho-680556
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
3. Respiratory viruses PROCESS_OF Homo sapiens
Subject
Respiratory viruses
Predicate
PROCESS_OF
Object
Homo sapiens
4. Illness (finding) PROCESS_OF Vulnerable Populations
Subject
Illness (finding)
Predicate
PROCESS_OF
Object
Vulnerable Populations
5. Brain LOCATION_OF Virus
Subject
Brain
Predicate
LOCATION_OF
Object
Virus
6. Respiratory viruses CAUSES COVID-19
Subject
Respiratory viruses
Predicate
CAUSES
Object
COVID-19
7. COVID-19 COEXISTS_WITH SARS coronavirus
Subject
COVID-19
Predicate
COEXISTS_WITH
Object
SARS coronavirus
8. Brain LOCATION_OF Virus Diseases
Subject
Brain
Predicate
LOCATION_OF
Object
Virus Diseases
9. SARS coronavirus PROCESS_OF Homo sapiens
Subject
SARS coronavirus
Predicate
PROCESS_OF
Object
Homo sapiens
10. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
11. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
12. Esthesia PROCESS_OF Patients
Subject
Esthesia
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PROCESS_OF
Object
Patients
13. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
14. Neurologic Manifestations PROCESS_OF Patients
Subject
Neurologic Manifestations
Predicate
PROCESS_OF
Object
Patients
15. Respiratory viruses PROCESS_OF Homo sapiens
Subject
Respiratory viruses
Predicate
PROCESS_OF
Object
Homo sapiens
16. Illness (finding) PROCESS_OF Vulnerable Populations
Subject
Illness (finding)
Predicate
PROCESS_OF
Object
Vulnerable Populations
17. Brain LOCATION_OF Virus
Subject
Brain
Predicate
LOCATION_OF
Object
Virus
18. Respiratory viruses CAUSES COVID-19
Subject
Respiratory viruses
Predicate
CAUSES
Object
COVID-19
19. COVID-19 COEXISTS_WITH SARS coronavirus
Subject
COVID-19
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COEXISTS_WITH
Object
SARS coronavirus
20. Brain LOCATION_OF Virus Diseases
Subject
Brain
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LOCATION_OF
Object
Virus Diseases
21. SARS coronavirus PROCESS_OF Homo sapiens
Subject
SARS coronavirus
Predicate
PROCESS_OF
Object
Homo sapiens
22. Complication PROCESS_OF Patients
Subject
Complication
Predicate
PROCESS_OF
Object
Patients
23. Neurologic Symptoms PROCESS_OF Patients
Subject
Neurologic Symptoms
Predicate
PROCESS_OF
Object
Patients
24. Esthesia PROCESS_OF Patients
Subject
Esthesia
Predicate
PROCESS_OF
Object
Patients
ABSTRACT
Respiratory viruses are opportunistic pathogens that infect the upper respiratory tract in humans and cause severe illnesses, especially in vulnerable populations. Some viruses have neuroinvasive properties and activate the immune response in the brain. These immune events may be neuroprotective or they may cause long-term damage similar to what is seen in some neurodegenerative diseases. The new "Severe Acute Respiratory Syndrome Coronavirus 2" (SARS-CoV-2) is one of the Respiratory viruses causing highly acute lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical similarities to those reported in "Severe Acute Respiratory Syndrome Coronavirus"(SARS-CoV) and the "Middle East Respiratory Syndrome Coronavirus"(MERS-CoV) including neurological manifestation. To examine the possible neurological damage induced by SARS-CoV-2, it is necessary to understand the immune reactions to viral infection in the brain, and their short- and long-term consequences. Considering the similarities between SARS-CoV and SARS-CoV-2, which will be discussed, cooperative homological and phylogenetical studies lead us to question if SARS-CoV-2 can have similar neuroinvasive capacities and neuroinflammatiory events that may lead to the same short- and long-term neuropathologies that SARS-CoV had shown in human and animal models. To explain the neurological manifestation caused by SARS-CoV-2, we will present a literature review of 765 COVID-19 patients, in which 18% had neurological symptoms and complications, including encephalopathy, encephalitis and cerebrovascular pathologies, acute myelitis, and Guillain-Barré syndrome. Clinical studies describe anosmia or partial loss of the sense of smell as the most frequent symptom in COVID19 patients, suggesting that olfactory dysfunction and the initial ultrarapid immune responses could be a prognostic factor.
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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pneumonia, Viral / Vagus Nerve / Brain / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Тип исследования: Прогностическое исследование / Review Пределы темы: Люди Язык: английский Журнал: Neurol Sci Тематика журнала: Неврология Год: 2020 Тип: Статья Аффилированная страна: S10072-020-04575-3

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Полный текст: Имеется в наличии Коллекция: Международные базы данных база данных: MEDLINE Основная тема: Pneumonia, Viral / Vagus Nerve / Brain / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Тип исследования: Прогностическое исследование / Review Пределы темы: Люди Язык: английский Журнал: Neurol Sci Тематика журнала: Неврология Год: 2020 Тип: Статья Аффилированная страна: S10072-020-04575-3