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Crosstalk between COVID-19 and prostate cancer.
Bahmad, Hisham F; Abou-Kheir, Wassim.
  • Bahmad HF; Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
  • Abou-Kheir W; Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.
Prostate Cancer Prostatic Dis ; 23(4): 561-563, 2020 12.
Article in English | MEDLINE | ID: covidwho-680650
ABSTRACT
A new coronavirus, named SARS-CoV-2, emerged in Wuhan city, China, in December 2019 causing atypical pneumonia and affecting multiple body organs. The rapidly increasing numbers of infected patients and deaths due to COVID-19 disease necessitated declaring it as a global pandemic. Efforts were combined since then to rapidly develop a treatment and/or a vaccine to combat the deadly virus. Drug repurposing approach has been pursued as a temporary management tactic to treat COVID-19 patients. However, reports about the efficacy of many of the used drugs had been controversial with a dire need to keep the ongoing efforts for rapid development of new treatments. Promising data came out pointing to a possible hidden liaison between prostate cancer (PCa) and COVID-19, where androgen-deprivation therapies (ADT) used in PCa had been shown to instigate a protective role against COVID-19. Delving into the possible mechanisms underlying the crosstalk between COVID-19 and PCa alludes a potential association between SARS-CoV-2 targets on host epithelial cells and PCa genetic aberrations and molecular signatures, including AR and TMPRSS2. The question remains Can PCa treatments serve as potential therapeutic options for COVID-19 patients?
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Prostatic Neoplasms / Coronavirus Infections / Betacoronavirus / Androgen Antagonists Type of study: Observational study Topics: Long Covid / Vaccines Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Prostate Cancer Prostatic Dis Journal subject: Endocrinology / Neoplasms / Urology Year: 2020 Document Type: Article Affiliation country: S41391-020-0262-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Prostatic Neoplasms / Coronavirus Infections / Betacoronavirus / Androgen Antagonists Type of study: Observational study Topics: Long Covid / Vaccines Limits: Humans / Male Country/Region as subject: Asia Language: English Journal: Prostate Cancer Prostatic Dis Journal subject: Endocrinology / Neoplasms / Urology Year: 2020 Document Type: Article Affiliation country: S41391-020-0262-y