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An aurora of natural products-based drug discovery is coming.
Tong, Yaojun; Deng, Zixin.
  • Tong Y; The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.
  • Deng Z; State Key Laboratory of Microbial Metabolism, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.
Synth Syst Biotechnol ; 5(2): 92-96, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-680799
Semantic information from SemMedBD (by NLM)
1. Harvest Procedure USES Fruit
Subject
Harvest Procedure
Predicate
USES
Object
Fruit
2. Harvest Procedure USES Fruit
Subject
Harvest Procedure
Predicate
USES
Object
Fruit
ABSTRACT
Natural products (NPs), a nature's reservoir possessing enormous structural and functional diversity far beyond the current ability of chemical synthesis, are now proving themselves as most wonderful gifts from mother nature for human beings. Many of them have been used successfully as medicines, as well as the most important sources of drug leads, food additives, and many industry relevant products for millennia. Most notably, more than half of the antibiotics and anti-cancer drugs currently in use are, or derived from, natural products. However, the speed and outputs of NP-based drug discovery has been slowing down dramatically after the fruitful harvest of the "low-hanging fruit" during the golden age of 1950s-1960s. With recent scientific advances combining metabolic sciences and technology, multi-omics, big data, combinatorial biosynthesis, synthetic biology, genome editing technology (such as CRISPR), artificial intelligence (AI), and 3D printing, the "high-hanging fruit" is becoming more and more accessible with reduced costs. We are now more and more confident that a new age of natural products discovery is dawning.

Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Synth Syst Biotechnol Year: 2020 Document Type: Article Affiliation country: J.synbio.2020.05.003

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Synth Syst Biotechnol Year: 2020 Document Type: Article Affiliation country: J.synbio.2020.05.003