Your browser doesn't support javascript.
The role of cytokine profile and lymphocyte subsets in the severity of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis.
Akbari, Hamed; Tabrizi, Reza; Lankarani, Kamran B; Aria, Hamid; Vakili, Sina; Asadian, Fatemeh; Noroozi, Saam; Keshavarz, Pedram; Faramarz, Sanaz.
  • Akbari H; Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran; Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
  • Tabrizi R; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Lankarani KB; Health Policy Research Center, Institute of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Aria H; Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Bioinformatics and Computational Biology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Vakili S; Biochemistry Department, Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Asadian F; Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Noroozi S; Department of Biochemistry, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
  • Keshavarz P; Medical Imaging Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
  • Faramarz S; Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. Electronic address: sanaz.faramarz68@gmail.com.
Life Sci ; 258: 118167, 2020 Oct 01.
Article in English | MEDLINE | ID: covidwho-684176
ABSTRACT

AIMS:

This study aimed to make a comparison between the clinical laboratory-related factors, complete blood count (CBC) indices, cytokines, and lymphocyte subsets in order to distinguish severe coronavirus disease 2019 (COVID-19) cases from the non-severe ones. MATERIALS AND

METHODS:

Relevant studies were searched in PubMed, Embase, Scopus, and Web of Science databases until March 31, 2020. Cochrane's Q test and the I2 statistic were used to determine heterogeneity. We used the random-effect models to pool the weighted mean differences (WMDs) and 95% confidence intervals (CIs). KEY

FINDINGS:

Out of a total of 8557 initial records, 44 articles (50 studies) with 7865 patients (ranging from 13 to 1582), were included. Our meta-analyses with random-effect models showed a significant decrease in lymphocytes, monocyte, CD4+ T cells, CD8+ T cells, CD3 cells, CD19 cells, and natural killer (NK) cells and an increase in the white blood cell (WBC), neutrophils, neutrophil to lymphocyte ratio (NLR), C-reactive protein (CRP)/hs-CRP, erythrocyte sedimentation rate (ESR), ferritin, procalcitonin (PCT), and serum amyloid A (SAA), interleukin-2 (IL-2), IL-2R, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (INF-γ) in the severe group compared to the non-severe group. However, no significant differences were found in IL-1ß, IL-17, and CD4/CD8 T cell ratio between the two groups.

SIGNIFICANCE:

Decrease in total lymphocytes and lymphocyte subsets as well as the elevation of CRP, ESR, SAA, PCT, ferritin, and cytokines, but not IL-1ß and IL-17, were closely associated with COVID-19 severity, implying reliable indicators of severe COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Cytokines / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Life Sci Year: 2020 Document Type: Article Affiliation country: J.lfs.2020.118167

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocytes / Cytokines / Coronavirus Infections Type of study: Diagnostic study / Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: Life Sci Year: 2020 Document Type: Article Affiliation country: J.lfs.2020.118167