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Differences in Antibody Kinetics and Functionality Between Severe and Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infections.
Rijkers, Ger; Murk, Jean-Luc; Wintermans, Bas; van Looy, Bieke; van den Berge, Marcel; Veenemans, Jacobien; Stohr, Joep; Reusken, Chantal; van der Pol, Pieter; Reimerink, Johan.
  • Rijkers G; Department of Medical Microbiology and Immunology, Admiral De Ruyter Hospital, Goes, The Netherlands.
  • Murk JL; Microvida, location St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
  • Wintermans B; Science Department, University College Roosevelt, Middelburg, The Netherlands.
  • van Looy B; Microvida, location St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
  • van den Berge M; Department of Medical Microbiology and Immunology, Admiral De Ruyter Hospital, Goes, The Netherlands.
  • Veenemans J; Department of Medical Microbiology, Bravis Hospital, Roosendaal, The Netherlands.
  • Stohr J; Department of Medical Microbiology and Immunology, Admiral De Ruyter Hospital, Goes, The Netherlands.
  • Reusken C; Department of Internal Medicine, Admiral De Ruyter Hospital, Goes, The Netherlands.
  • van der Pol P; Department of Medical Microbiology and Immunology, Admiral De Ruyter Hospital, Goes, The Netherlands.
  • Reimerink J; Microvida, location St Elisabeth-Tweesteden Hospital, Tilburg, The Netherlands.
J Infect Dis ; 222(8): 1265-1269, 2020 09 14.
Article in English | MEDLINE | ID: covidwho-811305
ABSTRACT
We determined and compared the humoral immune response in patients with severe (hospitalized) and mild (nonhospitalized) coronavirus disease 2019 (COVID-19). Patients with severe disease (n = 38) develop a robust antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including immunoglobulin G and immunoglobulin A antibodies. The geometric mean 50% virus neutralization titer is 1240. SARS-CoV-2 infection was found in hospital personnel (n = 24), who developed mild symptoms necessitating leave of absence and self-isolation, but not hospitalization; 75% developed antibodies, but with low/absent virus neutralization (60% with titers <120). While severe COVID-19 patients develop a strong antibody response, mild SARS-CoV-2 infections induce a modest antibody response. Long-term monitoring will show whether these responses predict protection against future infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis