Your browser doesn't support javascript.
Cytokine Storm in COVID-19-Immunopathological Mechanisms, Clinical Considerations, and Therapeutic Approaches: The REPROGRAM Consortium Position Paper.
Bhaskar, Sonu; Sinha, Akansha; Banach, Maciej; Mittoo, Shikha; Weissert, Robert; Kass, Joseph S; Rajagopal, Santhosh; Pai, Anupama R; Kutty, Shelby.
  • Bhaskar S; Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium, REPROGRAM Immunity Sub-committee†.
  • Sinha A; Department of Neurology & Neurophysiology, Liverpool Hospital and South Western Sydney Local Health District, Sydney, NSW, Australia.
  • Banach M; Neurovascular Imaging Laboratory & NSW Brain Clot Bank, Ingham Institute for Applied Medical Research, The University of New South Wales, UNSW Medicine, Sydney, NSW, Australia.
  • Mittoo S; Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium, REPROGRAM Immunity Sub-committee†.
  • Weissert R; The University of New South Wales, UNSW Medicine, Sydney, NSW, Australia.
  • Kass JS; Pandemic Health System REsilience PROGRAM (REPROGRAM) Consortium, REPROGRAM Immunity Sub-committee†.
  • Rajagopal S; Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.
  • Pai AR; Cardiovascular Research Centre, University of Zielona Góra, Zielona Gora, Poland.
  • Kutty S; Department of Hypertension, Medical University of Lodz, Lodz, Poland.
Front Immunol ; 11: 1648, 2020.
Article in English | MEDLINE | ID: covidwho-685338
ABSTRACT
Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure. The phenomenon has been implicated in critically ill patients infected with SARS-CoV-2, the novel coronavirus implicated in COVID-19. Critically ill COVID-19 patients experiencing cytokine storm are believed to have a worse prognosis and increased fatality rate. In SARS-CoV-2 infected patients, cytokine storm appears important to the pathogenesis of several severe manifestations of COVID-19 acute respiratory distress syndrome, thromboembolic diseases such as acute ischemic strokes caused by large vessel occlusion and myocardial infarction, encephalitis, acute kidney injury, and vasculitis (Kawasaki-like syndrome in children and renal vasculitis in adult). Understanding the pathogenesis of cytokine storm will help unravel not only risk factors for the condition but also therapeutic strategies to modulate the immune response and deliver improved outcomes in COVID-19 patients at high risk for severe disease. In this article, we present an overview of the cytokine storm and its implications in COVID-19 settings and identify potential pathways or biomarkers that could be targeted for therapy. Leveraging expert opinion, emerging evidence, and a case-based approach, this position paper provides critical insights on cytokine storm from both a prognostic and therapeutic standpoint.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Critical Care / Betacoronavirus Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Cytokines / Coronavirus Infections / Critical Care / Betacoronavirus Type of study: Prognostic study Limits: Female / Humans / Male Language: English Journal: Front Immunol Year: 2020 Document Type: Article