Halting coronavirus polymerase.

Kirchdoerfer, Robert N

Kirchdoerfer, Robert N.

Kirchdoerfer RN; Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706 rnkirchdoerf@wisc.edu.

J Biol Chem ; 295(15): 4780-4781, 2020 04 10.

Article in English | MEDLINE | ID: covidwho-686585

ABSTRACT

ABSTRACT

The nucleotide analogue remdesivir is an investigational drug for the treatment of human coronavirus infection. Remdesivir is a phosphoramidate prodrug and is known to target viral RNA-dependent RNA polymerases. In this issue, Gordon et al. identify that remdesivir acts as a delayed RNA chain terminator for MERS-CoV polymerase complexes.

Subject(s)

Adenosine Monophosphate/analogs & derivatives; Alanine/analogs & derivatives; Antiviral Agents/pharmacology; Coronavirus Infections/drug therapy; Coronavirus/drug effects; Coronavirus/enzymology; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Adenosine Monophosphate/pharmacology; Alanine/pharmacology; Animals; Coronavirus/physiology; Coronavirus Infections/virology; Exonucleases; Humans; Pandemics; Virus Replication/drug effects

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / RNA-Dependent RNA Polymerase / Adenosine Monophosphate / Coronavirus Infections / Coronavirus / Alanine Limits: Animals / Humans Language: English Journal: J Biol Chem Year: 2020 Document Type: Article

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