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Potential Fast COVID-19 Containment With Trehalose.
Martinon, Daisy; Borges, Vanessa F; Gomez, Angela C; Shimada, Kenichi.
  • Martinon D; Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Borges VF; Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Gomez AC; Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
  • Shimada K; Division of Infectious Diseases and Immunology, Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Front Immunol ; 11: 1623, 2020.
Article in English | MEDLINE | ID: covidwho-687023
ABSTRACT
Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapidly spreading infection. Frontline healthcare workers are succumbing to the infection in their efforts to save lives. There is an urgency to develop treatments for COVID-19, yet there is limited clinical data on the efficacy of potential drug treatments. Countries worldwide implemented a stay-at-home order to "flatten the curve" and relieve the pressure on the health system, but it is uncertain how this will unfold after the economy reopens. Trehalose, a natural glucose disaccharide, is known to impair viral function through the autophagy system. Here, we propose trehalose as a potential preventative treatment for SARS-CoV-2 infection and transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Trehalose / Coronavirus Infections / Post-Exposure Prophylaxis / Pre-Exposure Prophylaxis / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Adult / Aged / Child / Humans / Middle aged Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.01623

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Trehalose / Coronavirus Infections / Post-Exposure Prophylaxis / Pre-Exposure Prophylaxis / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Adult / Aged / Child / Humans / Middle aged Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.01623