Potential Fast COVID-19 Containment With Trehalose.
Front Immunol
; 11: 1623, 2020.
Article
in English
| MEDLINE | ID: covidwho-687023
ABSTRACT
Countries worldwide have confirmed a staggering number of COVID-19 cases, and it is now clear that no country is immune to the SARS-CoV-2 infection. Resource-poor countries with weaker health systems are struggling with epidemics of their own and are now in a more uncertain situation with this rapidly spreading infection. Frontline healthcare workers are succumbing to the infection in their efforts to save lives. There is an urgency to develop treatments for COVID-19, yet there is limited clinical data on the efficacy of potential drug treatments. Countries worldwide implemented a stay-at-home order to "flatten the curve" and relieve the pressure on the health system, but it is uncertain how this will unfold after the economy reopens. Trehalose, a natural glucose disaccharide, is known to impair viral function through the autophagy system. Here, we propose trehalose as a potential preventative treatment for SARS-CoV-2 infection and transmission.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Trehalose
/
Coronavirus Infections
/
Post-Exposure Prophylaxis
/
Pre-Exposure Prophylaxis
/
Betacoronavirus
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Child
/
Humans
/
Middle aged
Language:
English
Journal:
Front Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Fimmu.2020.01623
Similar
MEDLINE
...
LILACS
LIS