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Serological detection of 2019-nCoV respond to the epidemic: A useful complement to nucleic acid testing
International Immunopharmacology ; 2020.
Article | WHO COVID | ID: covidwho-689157
ABSTRACT
Corona Virus Disease 2019 (COVID-19) has spread rapidly to more than 215 countries, with over 11 91 million reported cases and more than 540,000 deaths Rapid diagnosis remains a bottleneck for containing the epidemic We used an automated chemiluminescent immunoassay to detect serum IgM and IgG antibodies to the 2019-nCoV in 742 subjects, so as to observe the dynamic process of antibody production in COVID-19 disease and seroepidemiology in different populations Patients with COVID-19 were reactive (positive) for specific antibodies within 3-15 days after onset of symptoms Specific IgM and IgG levels increased with the progression of the disease The areas under the receiver operating characteristic curves for IgM and IgG were 0 984 and 1 000, respectively This antibody detection assay had good sensitivity and specificity The understanding of the dynamic serological changes of COVID-19 patients and the seroepidemiological situation of the population will be helpful to further control the epidemic of COVID-19

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Full text: Available Database: WHO COVID Type: Article Journal: International Immunopharmacology Clinical aspect: Diagnosis Year: 2020