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Evaluation of the immunogenicity of prime-boost vaccination with the replication-deficient viral vectored COVID-19 vaccine candidate ChAdOx1 nCoV-19.
Graham, Simon P; McLean, Rebecca K; Spencer, Alexandra J; Belij-Rammerstorfer, Sandra; Wright, Daniel; Ulaszewska, Marta; Edwards, Jane C; Hayes, Jack W P; Martini, Veronica; Thakur, Nazia; Conceicao, Carina; Dietrich, Isabelle; Shelton, Holly; Waters, Ryan; Ludi, Anna; Wilsden, Ginette; Browning, Clare; Bialy, Dagmara; Bhat, Sushant; Stevenson-Leggett, Phoebe; Hollinghurst, Philippa; Gilbride, Ciaran; Pulido, David; Moffat, Katy; Sharpe, Hannah; Allen, Elizabeth; Mioulet, Valerie; Chiu, Chris; Newman, Joseph; Asfor, Amin S; Burman, Alison; Crossley, Sylvia; Huo, Jiandong; Owens, Raymond J; Carroll, Miles; Hammond, John A; Tchilian, Elma; Bailey, Dalan; Charleston, Bryan; Gilbert, Sarah C; Tuthill, Tobias J; Lambe, Teresa.
  • Graham SP; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • McLean RK; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Spencer AJ; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Belij-Rammerstorfer S; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Wright D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Ulaszewska M; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Edwards JC; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Hayes JWP; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Martini V; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Thakur N; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Conceicao C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Dietrich I; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Shelton H; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Waters R; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Ludi A; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Wilsden G; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Browning C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Bialy D; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Bhat S; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Stevenson-Leggett P; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Hollinghurst P; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Gilbride C; Department of Microbial Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH UK.
  • Pulido D; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Moffat K; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Sharpe H; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Allen E; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Mioulet V; The Jenner Institute, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford, OX3 7DQ UK.
  • Chiu C; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Newman J; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Asfor AS; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Burman A; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Crossley S; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Huo J; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Owens RJ; Protein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute Rutherford Appleton Laboratory Harwell Oxford, Didcot, OX11 0FA UK.
  • Carroll M; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, OX3 7BN UK.
  • Hammond JA; Protein Production UK, Research Complex at Harwell, and Rosalind Franklin Institute Rutherford Appleton Laboratory Harwell Oxford, Didcot, OX11 0FA UK.
  • Tchilian E; Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, University of Oxford, Oxford, OX3 7BN UK.
  • Bailey D; Public Health England, Manor Farm Road, Salisbury, SP4 0JG UK.
  • Charleston B; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Gilbert SC; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Tuthill TJ; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
  • Lambe T; The Pirbright Institute, Ash Road, Pirbright, GU24 0NF UK.
NPJ Vaccines ; 5(1): 69, 2020.
Article in English | MEDLINE | ID: covidwho-689622
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
Semantic information from SemMedBD (by NLM)
1. human study USES Immunization
Subject
human study
Predicate
USES
Object
Immunization
2. Antibody Formation PROCESS_OF Family suidae
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Family suidae
3. human study USES Immunization
Subject
human study
Predicate
USES
Object
Immunization
4. Antibody Formation PROCESS_OF Family suidae
Subject
Antibody Formation
Predicate
PROCESS_OF
Object
Family suidae
ABSTRACT
Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: NPJ Vaccines Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Journal: NPJ Vaccines Year: 2020 Document Type: Article