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Focus on Receptors for Coronaviruses with Special Reference to Angiotensin- Converting Enzyme 2 as a Potential Drug Target - A Perspective.
Magrone, Thea; Magrone, Manrico; Jirillo, Emilio.
  • Magrone T; Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari, Italy.
  • Magrone M; Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari, Italy.
  • Jirillo E; Department of Basic Medical Sciences, Neuroscience and Sensory Organs, University of Bari, School of Medicine, Bari, Italy.
Endocr Metab Immune Disord Drug Targets ; 20(6): 807-811, 2020.
Article in English | MEDLINE | ID: covidwho-689779
Semantic information from SemMedBD (by NLM)
1. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
Predicate
PART_OF
Object
Intestines
2. Vitronecti STIMULATES C0023516
Subject
Vitronecti
Predicate
STIMULATES
Object
C0023516
3. Leptocyte LOCATION_OF Virus
Subject
Leptocyte
Predicate
LOCATION_OF
Object
Virus
4. Protein Subunits INTERACTS_WITH ACE2 gene|ACE2
Subject
Protein Subunits
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
5. ACE2 gene|ACE2 PART_OF Homo sapiens
Subject
ACE2 gene|ACE2
Predicate
PART_OF
Object
Homo sapiens
6. SARS coronavirus PROCESS_OF Homo sapiens
Subject
SARS coronavirus
Predicate
PROCESS_OF
Object
Homo sapiens
7. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
8. ACE2 gene|ACE2 PART_OF Patients
Subject
ACE2 gene|ACE2
Predicate
PART_OF
Object
Patients
9. ACE2 gene|ACE2 AFFECTS Down-Regulation
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Down-Regulation
10. angiotensin II STIMULATES Recepto
Subject
angiotensin II
Predicate
STIMULATES
Object
Recepto
11. ACE2 gene|ACE2 AFFECTS Acute Lung Injury
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Acute Lung Injury
12. Immune Cell LOCATION_OF ACE2 gene|ACE2
Subject
Immune Cell
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
13. receptor COEXISTS_WITH ACE2 gene|ACE2
Subject
receptor
Predicate
COEXISTS_WITH
Object
ACE2 gene|ACE2
14. IFNA1 DISRUPTS Severe Acute Respiratory Syndrome
Subject
IFNA1
Predicate
DISRUPTS
Object
Severe Acute Respiratory Syndrome
15. Mus LOCATION_OF Protein Subunits
Subject
Mus
Predicate
LOCATION_OF
Object
Protein Subunits
16. Middle East Respiratory Syndrome Coronavirus LOCATION_OF Protein Subunits
Subject
Middle East Respiratory Syndrome Coronavirus
Predicate
LOCATION_OF
Object
Protein Subunits
17. Mus LOCATION_OF Monoclonal Antibodies
Subject
Mus
Predicate
LOCATION_OF
Object
Monoclonal Antibodies
18. Antibodie PART_OF C0086418
Subject
Antibodie
Predicate
PART_OF
Object
C0086418
19. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
20. Interleukin-1 ASSOCIATED_WITH Syndrome
Subject
Interleukin-1
Predicate
ASSOCIATED_WITH
Object
Syndrome
21. interleukin-6 ASSOCIATED_WITH Syndrome
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
Syndrome
22. cytokine ASSOCIATED_WITH Syndrome
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Syndrome
23. Syndrome PROCESS_OF Patients
Subject
Syndrome
Predicate
PROCESS_OF
Object
Patients
24. Immunity COEXISTS_WITH Aging
Subject
Immunity
Predicate
COEXISTS_WITH
Object
Aging
25. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
26. Lung LOCATION_OF Acute failure
Subject
Lung
Predicate
LOCATION_OF
Object
Acute failure
27. ACE2 gene|ACE2 PREVENTS Acute failure
Subject
ACE2 gene|ACE2
Predicate
PREVENTS
Object
Acute failure
28. angiotensin II STIMULATES AGTR1 gene|AGTR1
Subject
angiotensin II
Predicate
STIMULATES
Object
AGTR1 gene|AGTR1
29. angiotensin II DISRUPTS Cell Growth
Subject
angiotensin II
Predicate
DISRUPTS
Object
Cell Growth
30. AGTR1 gene|AGTR1 DISRUPTS Cell Growth
Subject
AGTR1 gene|AGTR1
Predicate
DISRUPTS
Object
Cell Growth
31. Myocardial Infarction PROCESS_OF Rattus norvegicus
Subject
Myocardial Infarction
Predicate
PROCESS_OF
Object
Rattus norvegicus
32. olmesartan TREATS Hypertensive disease
Subject
olmesartan
Predicate
TREATS
Object
Hypertensive disease
33. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
34. losartan STIMULATES ACE2 gene|ACE2
Subject
losartan
Predicate
STIMULATES
Object
ACE2 gene|ACE2
35. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
36. ACE2 gene|ACE2 AFFECTS Renin-angiotensin system
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Renin-angiotensin system
37. Epithelial Cells LOCATION_OF ACE2 gene|ACE2
Subject
Epithelial Cells
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
38. resveratrol STIMULATES ACE2 gene|ACE2
Subject
resveratrol
Predicate
STIMULATES
Object
ACE2 gene|ACE2
39. polyphenols INTERACTS_WITH resveratrol
Subject
polyphenols
Predicate
INTERACTS_WITH
Object
resveratrol
40. SIRT1 gene|SIRT1 INHIBITS AGTR1 gene|AGTR1
Subject
SIRT1 gene|SIRT1
Predicate
INHIBITS
Object
AGTR1 gene|AGTR1
41. resveratrol AFFECTS Cell Survival
Subject
resveratrol
Predicate
AFFECTS
Object
Cell Survival
42. Ability MANIFESTATION_OF Negative Regulation of Apoptosis
Subject
Ability
Predicate
MANIFESTATION_OF
Object
Negative Regulation of Apoptosis
43. resveratrol AFFECTS COVID-19
Subject
resveratrol
Predicate
AFFECTS
Object
COVID-19
44. resveratrol TREATS Patients
Subject
resveratrol
Predicate
TREATS
Object
Patients
45. ACE2 gene|ACE2 AFFECTS Myocarditis
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Myocarditis
46. ACE2 gene|ACE2 AFFECTS Syndrome
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Syndrome
47. Myocarditis PROCESS_OF Patients
Subject
Myocarditis
Predicate
PROCESS_OF
Object
Patients
48. Angiotensin-Converting Enzyme Inhibitors INTERACTS_WITH ACE2 gene|ACE2
Subject
Angiotensin-Converting Enzyme Inhibitors
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
49. Angiotensin II Type 1 Receptor Blockers INTERACTS_WITH ACE2 gene|ACE2
Subject
Angiotensin II Type 1 Receptor Blockers
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
50. ACE2 gene|ACE2 NEG_PART_OF Virus
Subject
ACE2 gene|ACE2
Predicate
NEG_PART_OF
Object
Virus
51. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
Predicate
PART_OF
Object
Intestines
52. Vitronectin, human STIMULATES Leukocytes
Subject
Vitronectin, human
Predicate
STIMULATES
Object
Leukocytes
53. Leptocyte LOCATION_OF Virus
Subject
Leptocyte
Predicate
LOCATION_OF
Object
Virus
54. Protein Subunits INTERACTS_WITH ACE2 gene|ACE2
Subject
Protein Subunits
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
55. ACE2 gene|ACE2 PART_OF Homo sapiens
Subject
ACE2 gene|ACE2
Predicate
PART_OF
Object
Homo sapiens
56. SARS coronavirus PROCESS_OF Homo sapiens
Subject
SARS coronavirus
Predicate
PROCESS_OF
Object
Homo sapiens
57. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
58. ACE2 gene|ACE2 PART_OF Patients
Subject
ACE2 gene|ACE2
Predicate
PART_OF
Object
Patients
59. ACE2 gene|ACE2 AFFECTS Down-Regulation
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Down-Regulation
60. angiotensin II STIMULATES Receptor, Angiotensin, Type 1a
Subject
angiotensin II
Predicate
STIMULATES
Object
Receptor, Angiotensin, Type 1a
61. ACE2 gene|ACE2 AFFECTS Acute Lung Injury
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Acute Lung Injury
62. Immune Cell LOCATION_OF ACE2 gene|ACE2
Subject
Immune Cell
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
63. receptor COEXISTS_WITH ACE2 gene|ACE2
Subject
receptor
Predicate
COEXISTS_WITH
Object
ACE2 gene|ACE2
64. IFNA1 DISRUPTS Severe Acute Respiratory Syndrome
Subject
IFNA1
Predicate
DISRUPTS
Object
Severe Acute Respiratory Syndrome
65. Mus LOCATION_OF Protein Subunits
Subject
Mus
Predicate
LOCATION_OF
Object
Protein Subunits
66. Middle East Respiratory Syndrome Coronavirus LOCATION_OF Protein Subunits
Subject
Middle East Respiratory Syndrome Coronavirus
Predicate
LOCATION_OF
Object
Protein Subunits
67. Mus LOCATION_OF Monoclonal Antibodies
Subject
Mus
Predicate
LOCATION_OF
Object
Monoclonal Antibodies
68. Antibodies, Neutralizing PART_OF Homo sapiens
Subject
Antibodies, Neutralizing
Predicate
PART_OF
Object
Homo sapiens
69. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
70. Interleukin-1 ASSOCIATED_WITH Syndrome
Subject
Interleukin-1
Predicate
ASSOCIATED_WITH
Object
Syndrome
71. interleukin-6 ASSOCIATED_WITH Syndrome
Subject
interleukin-6
Predicate
ASSOCIATED_WITH
Object
Syndrome
72. cytokine ASSOCIATED_WITH Syndrome
Subject
cytokine
Predicate
ASSOCIATED_WITH
Object
Syndrome
73. Syndrome PROCESS_OF Patients
Subject
Syndrome
Predicate
PROCESS_OF
Object
Patients
74. Immunity COEXISTS_WITH Aging
Subject
Immunity
Predicate
COEXISTS_WITH
Object
Aging
75. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
76. Lung LOCATION_OF Acute failure
Subject
Lung
Predicate
LOCATION_OF
Object
Acute failure
77. ACE2 gene|ACE2 PREVENTS Acute failure
Subject
ACE2 gene|ACE2
Predicate
PREVENTS
Object
Acute failure
78. angiotensin II STIMULATES AGTR1 gene|AGTR1
Subject
angiotensin II
Predicate
STIMULATES
Object
AGTR1 gene|AGTR1
79. angiotensin II DISRUPTS Cell Growth
Subject
angiotensin II
Predicate
DISRUPTS
Object
Cell Growth
80. AGTR1 gene|AGTR1 DISRUPTS Cell Growth
Subject
AGTR1 gene|AGTR1
Predicate
DISRUPTS
Object
Cell Growth
81. Myocardial Infarction PROCESS_OF Rattus norvegicus
Subject
Myocardial Infarction
Predicate
PROCESS_OF
Object
Rattus norvegicus
82. olmesartan TREATS Hypertensive disease
Subject
olmesartan
Predicate
TREATS
Object
Hypertensive disease
83. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
84. losartan STIMULATES ACE2 gene|ACE2
Subject
losartan
Predicate
STIMULATES
Object
ACE2 gene|ACE2
85. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
86. ACE2 gene|ACE2 AFFECTS Renin-angiotensin system
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Renin-angiotensin system
87. Epithelial Cells LOCATION_OF ACE2 gene|ACE2
Subject
Epithelial Cells
Predicate
LOCATION_OF
Object
ACE2 gene|ACE2
88. resveratrol STIMULATES ACE2 gene|ACE2
Subject
resveratrol
Predicate
STIMULATES
Object
ACE2 gene|ACE2
89. polyphenols INTERACTS_WITH resveratrol
Subject
polyphenols
Predicate
INTERACTS_WITH
Object
resveratrol
90. SIRT1 gene|SIRT1 INHIBITS AGTR1 gene|AGTR1
Subject
SIRT1 gene|SIRT1
Predicate
INHIBITS
Object
AGTR1 gene|AGTR1
91. resveratrol AFFECTS Cell Survival
Subject
resveratrol
Predicate
AFFECTS
Object
Cell Survival
92. Ability MANIFESTATION_OF Negative Regulation of Apoptosis
Subject
Ability
Predicate
MANIFESTATION_OF
Object
Negative Regulation of Apoptosis
93. resveratrol AFFECTS COVID-19
Subject
resveratrol
Predicate
AFFECTS
Object
COVID-19
94. resveratrol TREATS Patients
Subject
resveratrol
Predicate
TREATS
Object
Patients
95. ACE2 gene|ACE2 AFFECTS Myocarditis
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Myocarditis
96. ACE2 gene|ACE2 AFFECTS Syndrome
Subject
ACE2 gene|ACE2
Predicate
AFFECTS
Object
Syndrome
97. Myocarditis PROCESS_OF Patients
Subject
Myocarditis
Predicate
PROCESS_OF
Object
Patients
98. Angiotensin-Converting Enzyme Inhibitors INTERACTS_WITH ACE2 gene|ACE2
Subject
Angiotensin-Converting Enzyme Inhibitors
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
99. Angiotensin II Type 1 Receptor Blockers INTERACTS_WITH ACE2 gene|ACE2
Subject
Angiotensin II Type 1 Receptor Blockers
Predicate
INTERACTS_WITH
Object
ACE2 gene|ACE2
100. ACE2 gene|ACE2 NEG_PART_OF Virus
Subject
ACE2 gene|ACE2
Predicate
NEG_PART_OF
Object
Virus

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Receptors, Virus / Coronavirus Infections / Coronavirus / Angiotensin-Converting Enzyme 2 Limits: Humans Language: English Journal: Endocr Metab Immune Disord Drug Targets Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2020 Document Type: Article Affiliation country: 1871530320666200427112902

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Receptors, Virus / Coronavirus Infections / Coronavirus / Angiotensin-Converting Enzyme 2 Limits: Humans Language: English Journal: Endocr Metab Immune Disord Drug Targets Journal subject: Allergy and Immunology / Endocrinology / Metabolism / Drug Therapy Year: 2020 Document Type: Article Affiliation country: 1871530320666200427112902