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Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.
Zhang, Jiaoyue; Kong, Wen; Xia, Pengfei; Xu, Ying; Li, Li; Li, Qin; Yang, Li; Wei, Qi; Wang, Hanyu; Li, Huiqing; Zheng, Juan; Sun, Hui; Xia, Wenfang; Liu, Geng; Zhong, Xueyu; Qiu, Kangli; Li, Yan; Wang, Han; Wang, Yuxiu; Song, Xiaoli; Liu, Hua; Xiong, Si; Liu, Yumei; Cui, Zhenhai; Hu, Yu; Chen, Lulu; Pan, An; Zeng, Tianshu.
  • Zhang J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Kong W; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Xia P; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu Y; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li L; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Q; Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.
  • Yang L; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Wei Q; Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.
  • Wang H; Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.
  • Li H; Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.
  • Zheng J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sun H; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Xia W; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu G; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Zhong X; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Qiu K; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang H; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Wang Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Song X; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Liu H; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiong S; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Liu Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cui Z; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Hu Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen L; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Pan A; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Zeng T; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne) ; 11: 525, 2020.
Article in English | MEDLINE | ID: covidwho-690147
Semantic information from SemMedBD (by NLM)
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Poor outcome
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Diabetes
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Impaired fasting glycemia
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PREDISPOSES
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hospitalized patients
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Patients
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PROCESS_OF
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Patients
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Patients
19. Impaired fasting glycemia PREDISPOSES Poor outcome
Subject
Impaired fasting glycemia
Predicate
PREDISPOSES
Object
Poor outcome
20. Diabetes PREDISPOSES Complication
Subject
Diabetes
Predicate
PREDISPOSES
Object
Complication
21. Impaired fasting glycemia PREDISPOSES Complication
Subject
Impaired fasting glycemia
Predicate
PREDISPOSES
Object
Complication
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Subject
Diabetes
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PROCESS_OF
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Patients
23. Impaired fasting glycemia PROCESS_OF Patients
Subject
Impaired fasting glycemia
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Patients
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Mechanical ventilation
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Patients
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Diabetes
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ABSTRACT

Background:

Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19.

Methods:

In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models.

Results:

The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities.

Conclusion:

IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Glucose Intolerance / Coronavirus Infections / Diabetes Complications / Diabetes Mellitus / Hyperglycemia Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fendo.2020.00525

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Glucose Intolerance / Coronavirus Infections / Diabetes Complications / Diabetes Mellitus / Hyperglycemia Type of study: Controlled clinical trial / Etiology study / Observational study / Prognostic study / Risk factors Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fendo.2020.00525