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Impaired Fasting Glucose and Diabetes Are Related to Higher Risks of Complications and Mortality Among Patients With Coronavirus Disease 2019.
Zhang, Jiaoyue; Kong, Wen; Xia, Pengfei; Xu, Ying; Li, Li; Li, Qin; Yang, Li; Wei, Qi; Wang, Hanyu; Li, Huiqing; Zheng, Juan; Sun, Hui; Xia, Wenfang; Liu, Geng; Zhong, Xueyu; Qiu, Kangli; Li, Yan; Wang, Han; Wang, Yuxiu; Song, Xiaoli; Liu, Hua; Xiong, Si; Liu, Yumei; Cui, Zhenhai; Hu, Yu; Chen, Lulu; Pan, An; Zeng, Tianshu.
  • Zhang J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Kong W; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Xia P; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xu Y; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li L; Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li Q; Department of Endocrinology, The Fifth Hospital of Wuhan, Wuhan, China.
  • Yang L; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Wei Q; Department of Endocrinology, General Hospital of the Yangtze River Shipping, Wuhan, China.
  • Wang H; Department of Endocrinology, Hankou Hospital of Wuhan City, Wuhan, China.
  • Li H; Department of Endocrinology, Red Cross Hospital of Wuhan City, Wuhan, China.
  • Zheng J; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Sun H; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Xia W; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Liu G; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Zhong X; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Qiu K; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Li Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wang H; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Wang Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Song X; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Liu H; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiong S; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Liu Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cui Z; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Hu Y; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Chen L; Hubei Provincial Clinical Research Center for Diabetes and Metabolic Disorders, Wuhan, China.
  • Pan A; Department of Endocrinology, Wuhan Wuchang Hospital, Wuchang Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, China.
  • Zeng T; Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Endocrinol (Lausanne) ; 11: 525, 2020.
Article in English | MEDLINE | ID: covidwho-690147
ABSTRACT

Background:

Diabetes correlates with poor prognosis in patients with COVID-19, but very few studies have evaluated whether impaired fasting glucose (IFG) is also a risk factor for the poor outcomes of patients with COVID-19. Here we aimed to examine the associations between IFG and diabetes at admission with risks of complications and mortality among patients with COVID-19.

Methods:

In this multicenter retrospective cohort study, we enrolled 312 hospitalized patients with COVID-19 from 5 hospitals in Wuhan from Jan 1 to Mar 17, 2020. Clinical information, laboratory findings, complications, treatment regimens, and mortality status were collected. The associations between hyperglycemia and diabetes status at admission with primary composite end-point events (including mechanical ventilation, admission to intensive care unit, or death) were analyzed by Cox proportional hazards regression models.

Results:

The median age of the patients was 57 years (interquartile range 38-66), and 172 (55%) were women. At the time of hospital admission, 84 (27%) had diabetes (and 36 were new-diagnosed), 62 (20%) had IFG, and 166 (53%) had normal fasting glucose (NFG) levels. Compared to patients with NFG, patients with IFG and diabetes developed more primary composite end-point events (9 [5%], 11 [18%], 26 [31%]), including receiving mechanical ventilation (5 [3%], 6 [10%], 21 [25%]), and death (4 [2%], 9 [15%], 20 [24%]). Multivariable Cox regression analyses showed diabetes was associated increased risks of primary composite end-point events (hazard ratio 3.53; 95% confidence interval 1.48-8.40) and mortality (6.25; 1.91-20.45), and IFG was associated with an increased risk of mortality (4.11; 1.15-14.74), after adjusting for age, sex, hospitals and comorbidities.

Conclusion:

IFG and diabetes at admission were associated with higher risks of adverse outcomes among patients with COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Glucose Intolerance / Coronavirus Infections / Diabetes Complications / Diabetes Mellitus / Hyperglycemia Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fendo.2020.00525

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Glucose / Glucose Intolerance / Coronavirus Infections / Diabetes Complications / Diabetes Mellitus / Hyperglycemia Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Country/Region as subject: Asia Language: English Journal: Front Endocrinol (Lausanne) Year: 2020 Document Type: Article Affiliation country: Fendo.2020.00525