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SARS-CoV-2 seroprevalence among parturient women in Philadelphia.
Flannery, Dustin D; Gouma, Sigrid; Dhudasia, Miren B; Mukhopadhyay, Sagori; Pfeifer, Madeline R; Woodford, Emily C; Gerber, Jeffrey S; Arevalo, Claudia P; Bolton, Marcus J; Weirick, Madison E; Goodwin, Eileen C; Anderson, Elizabeth M; Greenplate, Allison R; Kim, Justin; Han, Nicholas; Pattekar, Ajinkya; Dougherty, Jeanette; Kuthuru, Oliva; Mathew, Divij; Baxter, Amy E; Vella, Laura A; Weaver, JoEllen; Verma, Anurag; Leite, Rita; Morris, Jeffrey S; Rader, Daniel J; Elovitz, Michal A; Wherry, E John; Puopolo, Karen M; Hensley, Scott E.
  • Flannery DD; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Gouma S; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Dhudasia MB; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Mukhopadhyay S; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Pfeifer MR; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Woodford EC; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Gerber JS; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Arevalo CP; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Bolton MJ; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Weirick ME; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Goodwin EC; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Anderson EM; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Greenplate AR; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Kim J; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Han N; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Pattekar A; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Dougherty J; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Kuthuru O; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Mathew D; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Baxter AE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Vella LA; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.
  • Weaver J; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Verma A; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.
  • Leite R; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Morris JS; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.
  • Rader DJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Elovitz MA; Division of Gastroenterology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Wherry EJ; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Puopolo KM; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA.
  • Hensley SE; Institute for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Sci Immunol ; 5(49)2020 07 29.
Article in English | MEDLINE | ID: covidwho-690482
ABSTRACT
Limited data are available for pregnant women affected by SARS-CoV-2. Serological tests are critically important for determining SARS-CoV-2 exposures within both individuals and populations. We validated a SARS-CoV-2 spike receptor binding domain serological test using 834 pre-pandemic samples and 31 samples from COVID-19 recovered donors. We then completed SARS-CoV-2 serological testing of 1,293 parturient women at two centers in Philadelphia from April 4 to June 3, 2020. We found 80/1,293 (6.2%) of parturient women possessed IgG and/or IgM SARS-CoV-2-specific antibodies. We found race/ethnicity differences in seroprevalence rates, with higher rates in Black/non-Hispanic and Hispanic/Latino women. Of the 72 seropositive women who also received nasopharyngeal polymerase chain reaction testing during pregnancy, 46 (64%) were positive. Continued serologic surveillance among pregnant women may inform perinatal clinical practices and can potentially be used to estimate exposure to SARS-CoV-2 within the community.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Health Status Disparities / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Country/Region as subject: North America Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abd5709

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Health Status Disparities / Betacoronavirus / Antibodies, Viral Type of study: Diagnostic study / Etiology study / Incidence study / Observational study / Risk factors Country/Region as subject: North America Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abd5709