[COVID-19: The Perspective Of Nephrology]. / COVID-19 aus Sicht des Nephrologen.
Dtsch Med Wochenschr
; 145(15): 1068-1073, 2020 Jul.
Article
in German
| MEDLINE | ID: covidwho-690651
ABSTRACT
Increasing insight into the clinical phenotype and mechanisms of SARS-CoV-2 infections and COVID-19 has identified damage of the kidneys as a key player in the course of the disease. This manuscript summarizes the current knowledge on direct viral infection of kidney tissue, proteinuria and acute kidney injury in COVID-19, and management of patients on chronic dialysis as well as after kidney transplantation. Direct infection of podocytes and proximal tubular cells by SARS-CoV-2 has been confirmed and results in proteinuria and hematuria at an early stage of COVID-19. In this context, any kidney affection is a predictor of worse outcomes among COVID-19 patients irrespective of the initial presentation and increases the risk of acute kidney injury. Specific therapies for kidney damage and acute kidney injury within COVID-19 that could be generally recommended are currently lacking. Patients on chronic hemodialysis in particular are at risk for contracting SARS-CoV-2 infections as indicated by outbreaks and super-spreading events in hemodialysis facilities. Immunosuppressive therapy after kidney transplantation needs to be adapted upon diagnosis of COVID-19 depending on the severity of the initial presentation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Acute Kidney Injury
/
Pandemics
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
German
Journal:
Dtsch Med Wochenschr
Year:
2020
Document Type:
Article
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