Differential Tropism of SARS-CoV and SARS-CoV-2 in Bat Cells.
Emerg Infect Dis
; 26(12): 2961-2965, 2020 12.
Article
in English
| MEDLINE | ID: covidwho-690716
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 did not replicate efficiently in 13 bat cell lines, whereas severe acute respiratory syndrome coronavirus replicated efficiently in kidney cells of its ancestral host, the Rhinolophus sinicus bat, suggesting different evolutionary origins. Structural modeling showed that RBD/RsACE2 binding may contribute to the differential cellular tropism.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Severe acute respiratory syndrome-related coronavirus
/
Viral Tropism
/
SARS-CoV-2
Limits:
Animals
/
Humans
Language:
English
Journal:
Emerg Infect Dis
Journal subject:
Communicable Diseases
Year:
2020
Document Type:
Article
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