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Fat mass affects nutritional status of ICU COVID-19 patients.
De Lorenzo, Antonino; Tarsitano, Maria Grazia; Falcone, Carmela; Di Renzo, Laura; Romano, Lorenzo; Macheda, Sebastiano; Ferrarelli, Anna; Labate, Demetrio; Tescione, Marco; Bilotta, Federico; Gualtieri, Paola.
  • De Lorenzo A; Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Tarsitano MG; Department of Experimental Medicine, University of Rome Sapienza, 00161, Rome, Italy.
  • Falcone C; Unit of Radiology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124, Reggio Calabria, Italy.
  • Di Renzo L; Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Romano L; School of Specialization in Food Science, University of Rome Tor Vergata, 00133, Rome, Italy.
  • Macheda S; Unit of Intensive Care Medicine and Anesthesia, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124, Reggio Calabria, Italy.
  • Ferrarelli A; Unit of Radiology, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124, Reggio Calabria, Italy.
  • Labate D; Unit of Intensive Care Medicine and Anesthesia, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124, Reggio Calabria, Italy.
  • Tescione M; Unit of Intensive Care Medicine and Anesthesia, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, 89124, Reggio Calabria, Italy.
  • Bilotta F; Department of Anesthesiology and Critical Care, University of Rome Sapienza, 00161, Rome, Italy.
  • Gualtieri P; Section of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133, Rome, Italy. paola.gualtieri@uniroma2.it.
J Transl Med ; 18(1): 299, 2020 08 03.
Article in English | MEDLINE | ID: covidwho-691901
ABSTRACT

BACKGROUND:

Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is the organ playing the crucial role. So, it is necessary to evaluate fat mass and not simpler body mass index (BMI), because BMI leaves a portion of the obese population unrecognized. The aim is to evaluate the relationship between Percentage of Fat Mass (FM%) and immune-inflammatory response, after 10 days in Intensive Care Unit (ICU).

METHODS:

Prospective observational study of 22 adult patients, affected by COVID-19 pneumonia and admitted to the ICU and classified in two sets (10) lean and (12) obese, according to FM% and age (De Lorenzo classification). Patients were analyzed at admission in ICU and at 10th day.

RESULTS:

Obese have steatosis, impaired hepatic function, compromise immune response and higher inflammation. In addition, they have a reduced prognostic nutritional index (PNI), nutritional survival index for ICU patients.

CONCLUSION:

This is the first study evaluating FM% in COVID-19 patient. We underlined obese characteristic with likely poorly prognosis and an important misclassification of obesity. A not negligible number of patients with normal BMI could actually have an excess of adipose tissue and therefore have an unfavorable outcome such as an obese. Is fundamental personalized patients nutrition basing on disease phases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Nutritional Status / Coronavirus Infections / Critical Care / Adiposity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02464-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Nutritional Status / Coronavirus Infections / Critical Care / Adiposity Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: J Transl Med Year: 2020 Document Type: Article Affiliation country: S12967-020-02464-z