Teaching Old Drugs New Tricks: Statins for COVID-19?

Fajgenbaum, David C; Rader, Daniel J

Fajgenbaum, David C; Rader, Daniel J.

Fajgenbaum DC; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rader DJ; Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: rader@pennmedicine.upenn.edu.

Cell Metab ; 32(2): 145-147, 2020 08 04.

Article in English | MEDLINE | ID: covidwho-691958

ABSTRACT

ABSTRACT

The COVID-19 pandemic has driven unprecedented efforts to identify existing treatments that can be quickly and effectively repurposed to reduce morbidity and mortality. In this issue of Cell Metabolism, Zhang et al. (2020) report an association between statin use and improved outcomes in a large observational study of hospitalized COVID-19 patients. Given the widespread availability, low cost, and safety of statins, this promising result should be further investigated in randomized controlled trials.

Subject(s)

Betacoronavirus/drug effects; Coronavirus Infections/drug therapy; Drug Repositioning/methods; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use; Pneumonia, Viral/drug therapy; COVID-19; Cytokine Release Syndrome/drug therapy; Humans; Observational Studies as Topic; Pandemics; SARS-CoV-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Drug Repositioning / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Cell Metab Journal subject: Metabolism Year: 2020 Document Type: Article Affiliation country: J.cmet.2020.07.006

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