Your browser doesn't support javascript.
Emergence of SARS-CoV-2 through recombination and strong purifying selection.
Li, Xiaojun; Giorgi, Elena E; Marichannegowda, Manukumar Honnayakanahalli; Foley, Brian; Xiao, Chuan; Kong, Xiang-Peng; Chen, Yue; Gnanakaran, S; Korber, Bette; Gao, Feng.
  • Li X; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Giorgi EE; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
  • Marichannegowda MH; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Foley B; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
  • Xiao C; Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA.
  • Kong XP; Department of Biochemistry and Molecular Pharmacology, Grossman School of Medicine, New York University, New York, NY 10016, USA.
  • Chen Y; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
  • Gnanakaran S; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
  • Korber B; Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, NM 87544, USA.
  • Gao F; New Mexico Consortium, Los Alamos, NM 87545, USA.
Sci Adv ; 6(27)2020 07.
Article in English | MEDLINE | ID: covidwho-692265
ABSTRACT
COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2. Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis, discovering new drugs, and developing a vaccine. We show evidence of strong purifying selection around the receptor binding motif (RBM) in the spike and other genes among bat, pangolin, and human coronaviruses, suggesting similar evolutionary constraints in different host species. We also demonstrate that SARS-CoV-2's entire RBM was introduced through recombination with coronaviruses from pangolins, possibly a critical step in the evolution of SARS-CoV-2's ability to infect humans. Similar purifying selection in different host species, together with frequent recombination among coronaviruses, suggests a common evolutionary mechanism that could lead to new emerging human coronaviruses.
Subject(s)
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Recombination, Genetic / Coronavirus Infections / Betacoronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Sciadv.abb9153

Similar

MEDLINE
LILACS
LIS
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Recombination, Genetic / Coronavirus Infections / Betacoronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Sciadv.abb9153