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The characteristics and predictive role of lymphocyte subsets in COVID-19 patients.
Zhang, Wenjing; Li, Lei; Liu, Jihai; Chen, Li; Zhou, Fangfang; Jin, Ting; Jiang, Lin; Li, Xiang; Yang, Ming; Wang, Hongxiang.
  • Zhang W; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Li L; Department of Surgery, Wuhan Jinyintan Hospital, Wuhan, Hubei province, 430023, China.
  • Liu J; Department of Surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Chen L; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Zhou F; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Jin T; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Jiang L; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Li X; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Yang M; Department of Plastic surgery, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
  • Wang H; Department of Hematology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei province, 430014, China.
Int J Infect Dis ; 99: 92-99, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-2311415
ABSTRACT

OBJECTIVE:

To investigate the characteristics and predictive roles of lymphocyte subsets in COVID-19 patients.

METHOD:

We evaluated lymphocyte subsets and other clinical features of COVID-19 patients, and analyzed their potential impacts on COVID-19 outcomes.

RESULTS:

1. Lymphocyte subset counts in the peripheral blood of patients with COVID-19 were significantly reduced, especially in patients with severe disease. 2. In patients with non-severe disease, the time from symptom onset to hospital admission was positively correlated with total T cell counts. 3. Among COVID-19 patients who did not reach the composite endpoint, lymphocyte subset counts were higher than in patients who had reached the composite endpoint. 4. The Kaplan-Meier survival curves showed significant differences in COVID-19 patients, classified by the levels of total, CD8+, and CD4+ T cells at admission.

CONCLUSION:

Our study showed that total, CD8+, and CD4+ T cell counts in patients with COVID-19 were significantly reduced, especially in patients with severe disease. Lower T lymphocyte subsets were significantly associated with a higher occurrence of composite endpoint events. These subsets may help identify patients with a high risk of composite endpoint events.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.06.079

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus Type of study: Experimental Studies / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Int J Infect Dis Journal subject: Communicable Diseases Year: 2020 Document Type: Article Affiliation country: J.ijid.2020.06.079